- Synthesis of Rare Polyunsaturated Fatty Acids: Stearidonic and ω-3 Arachidonic
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Total chemical syntheses of the rare natural ω-3 C18 and C20 fatty acids, which possess potential antiinflammatory activity, were elaborated for subsequent studies of their biological activity.
- Golovanov,Ivanov,Groza,Myagkova
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p. 1038 - 1041
(2016/02/18)
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- METHODS FOR THE SYNTHESIS OF 13C LABELED DHA AND USE AS A REFERENCE STANDARD
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A method for preparing 13C labeled docosahexaenoic acid (DHA) represented by Formula A: The method comprises the conversion of 2-pentyn-l-ol to 13C labeled DHA by reaction with propargyl alcohol, 13C labeled propargyl alco
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Page/Page column 20-21
(2013/06/05)
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- METHOD FOR THE SYNTHESIS OF DHA
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A method for preparing docosahexaenoic acid (DHA). The method comprises coupling a compound represented by Formula I with a compound represented by Formula II followed by partial hydrogenation to obtain a compound represented by Formula III. The compound represented by Formula III acts as a DHA precursor and thus can be hydrolysed to obtain DHA. Novel starting materials represented by Formula I and Formula II, and synthetic routes for preparing the same are also provided.
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- A Novel Synthesis of (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic Acid and Its Acetylenic Precursor
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A novel procedure of synthesis of (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic (timnodonic) acid and its acetylenic precursor, 5,8,11,14,17-eicosapentaynoic acid was developed.It uses polyacetylene strategy and a known reaction of cross-coupling between propargyl units and ω-acetylenes in the presence of copper(I) and sodium iodides and involves the in situ formation of organocopper compounds and propargyl iodides. - Key words: (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid; 5,8,11,14,17-eicosapentaynoic acid; polyacetylenic alcohols; cross-coupling
- Ivanov, I. V.,Groza, N. V.,Myagkova, G. I.
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p. 819 - 822
(2007/10/03)
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- SYNTHESES OF OPTICALLY ACTIVE PHEROMONES WITH AN EPOXY RING, (+)-DISPARLURE AND BOTH THE ENANTIOMERS OF (3Z,6Z)-cis-9,10-EPOXY-3,6-HENEICOSADIENE
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(+)-Disparlure 1 and both the enantiomers of (3Z,6Z)-cis-9,10-epoxy-3,6-heneicosadiene 2 were synthesized in optically pure forms employing the Sharpless asymmetric epoxidation as the key-step.The natural pheromone 2 isolated from Estigmene acrea was shown to possess (9S,10R)-stereochemistry.
- Mori, Kenji,Ebata, Takashi
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p. 3471 - 3478
(2007/10/02)
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- TOTAL SYNTHESIS OF LEUKOTRIENE B5
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A practical, stereocontrolled synthesis of leukotriene B5 is described which makes this substance readily available for the first time.
- Corey, E. J.,Pyne, Stephen G.,Su, Wei-Gou
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p. 4883 - 4886
(2007/10/02)
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