- Practical and general method for the direct synthesis of alkyl fluorides from alcohols under mild conditions: A reinvestigation
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In contrast to the results presented in a previous report, the direct conversion of alcohols to alkyl fluorides with triphenylphosphine and potassium fluoride in CCl4/DMF under mild conditions failed.
- Rupprich, Marco,Decristoforo, Clemens,Matuszczak, Barbara
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- A mild method for the replacement of a hydroxyl group by halogen. 1. Scope and chemoselectivity
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α-Chloro-, bromo- and iodoenamines, which are readily prepared from the corresponding isobutyramides have been found to be excellent reagents for the transformation of a wide variety of alcohols or carboxylic acids into the corresponding halides. Yields are high and conditions are very mild thus allowing for the presence of sensitive functional groups. The reagents can be easily tuned allowing therefore the selective monohalogenation of polyhydroxylated molecules. The scope and chemoselectivity of the reactions have been studied and reaction mechanisms have been proposed.
- Munyemana, Fran?ois,George, Isabelle,Devos, Alain,Colens, Alain,Badarau, Eduard,Frisque-Hesbain, Anne-Marie,Loudet, Aurore,Differding, Edmond,Damien, Jean-Marie,Rémion, Jeanine,Van Uytbergen, Jacqueline,Ghosez, Léon
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p. 420 - 430
(2015/12/31)
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- Synthesis and biological evaluation of nitric oxide-donating thalidomide analogues as anticancer agents
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In search of more potent anticancer agents, 15 nitric oxide (NO)-donating thalidomide analogues, 6a, 6b, 8a-8e, and 13a-13h, were designed and synthesized. Cytotoxicity of these compounds was evaluated in vitro against three human tumor cell lines (HepG2, A549, and PC-3). The results indicated that 13a-13d exhibited notable anticancer activities comparable to or stronger than that of 5-fluorouracil (5-FU). Structure-activity relationships were also discussed, based on the experimental data obtained. Generally, the cytotoxic activity of target compounds is closely related to the type of NO donors, and the length of the spacers connecting to NO donors also appears important for the bioactivities.
- Wang, Tao,Zhang, Yi-Hua,Kong, Xiang-Wen,Lai, Yi-Sheng,Ji, Hui,Chen, Yan-Ping,Peng, Si-Xun
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experimental part
p. 466 - 474
(2010/04/23)
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- Facile and selective deprotection of aryl acetates using sodium perborate under mild and neutral conditions
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A variety of aryl acetates are cleaved to the corresponding phenols using sodium perborate in methanol under mild conditions (25°C). The effectiveness of this protocol is manifested in its tolerance of different functional groups and selectivity of deprotection towards aryl acetates whereas alkyl acetates are found to be unreactive under these reaction conditions.
- Bandgar, Babasaheb P.,Uppalla, Lavkumar S.,Sadavarte, Vaibhav S.,Patil, Suresh V.
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p. 1273 - 1276
(2007/10/03)
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- Microwave assisted selective cleavage of sulfonates and sulfonamides in dry media
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A simple and efficient method for the cleavage of Sulfonates and Sulfonamides has been achieved for the first time under microwave irradiation conditions using KF-Al2O3.
- Sabitha, Gowravaram,Abraham, Sunny,Reddy, B. V. Subba,Yadav
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p. 1745 - 1746
(2007/10/03)
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- Immonium salts and derivatives thereof
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There are provided: novel aryloxy immonium salts, prepared by the reaction of their corresponding haloformates with amides; and phenolic compositions corresponding to the aryloxy immonium salts. These novel aryloxy immonium salts and their corresponding phenolic compositions have utility as chemical intermediates, antioxidants, stabilizers and antibacterials.
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- Process for tris(aralkyl)phosphines
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In a solution that is free of bases and free of oxygen and which contains at least four molar proportions of the reactant tris(hydroxymethyl)phosphine for every three molar proportions of an aralkyl halide reactant, the following reaction produces tris(aralkyl)phosphine product: after separation of the phosphine product, the phosphonium salt by-products can be converted to tris(hydroxymethyl)phosphine by the addition of a base.
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- Immonium salts and derivatives thereof
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There are provided: novel aryloxy immonium salts, prepared by the reaction of their corresponding haloformates with amides; and phenolic compositions corresponding to the aryloxy immonium salts. These novel aryloxy immonium salts and their corresponding phenolic compositions have utility as chemical intermediates, antioxidants, stabilizers and antibacterials.
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