- Ultrasonic assisted synthesis of gem-dichloroaziridine derivatives using Mg/CCl4 under neutral conditions
-
A novel and convenient method for synthesis of gem-dichloroaziridine derivatives was reported in that was utilized Mg powder with CCl4 for dichlorocarbene generation under ultrasonic irradiation. In this clean and efficient reaction procedure,
- Rabiei, Khadijeh,Naeimi, Hossein
-
p. 150 - 154
(2015/01/30)
-
- PEG400-enhanced synthesis of gem-dichloroaziridines and gem-dichlorocyclopropanes via in situ generated dichlorocarbene
-
PEG400 is employed as an efficient phase transfer catalyst for the cycloaddition reaction of imines with dichlorocarbene, which is generated in situ from chloroform and sodium hydroxide, to give gem-dichloroaziridines in moderate to excellent yields at ambient temperature. This protocol is also extended to the synthesis of cyclopropanes from a variety of alkenes. In this study, PEG400 behaves as a phase transfer reagent thanks to its ability to coordinate with alkali metal cations. Notably, the one-pot synthesis of gem-dichloroaziridines from benzaldehyde and aromatic amines has also been successfully performed. The in situ generated acid, derived from CO2 and H2O, can also be effectively applied to promote the amide synthesis via the gem-dichloroaziridine pathway. The application of the gem-dichlorocyclopropane as a platform chemical is also briefly demonstrated, to afford the 2-phenylacrylaldehyde derivative via a ring-opening reaction. The Royal Society of Chemistry 2013.
- Song, Qing-Wen,Yu, Bing,Liu, An-Hua,He, Ying,Yang, Zhen-Zhen,Diao, Zhen-Feng,Song, Qing-Chuan,Li, Xue-Dong,He, Liang-Nian
-
p. 19009 - 19014
(2013/10/22)
-
- Nanocrystalline magnesium oxide as a solid base catalyst promoted one pot synthesis of gem-dichloroaziridine derivatives under thermal conditions
-
In this study, efficient and mild synthesis of gem-dichloroaziridines from Schiff bases in the presence of nanocrystalline magnesium oxide/chloroform as a novel source of dichlorocarbene intermediate under thermal conditions have been described. The react
- Naeimi,Rabiei, Kh.,Rezaei,Meshkani
-
p. 161 - 167
(2013/02/25)
-
- A novel catalyst-free one-pot synthesis of some new N-(α- hydroxybenzyl)formamides by treatment of 2,2-dichloroaziridines with dimethyl sulfoxide and water under neutral conditions
-
A novel, mild, and efficient method is reported for the preparation of new N-(α-hydroxybenzyl)formamides in excellent yields and appropriate reaction times through the reaction of 2,2-dichloroaziridines with aqueous DMSO as the O-donor under neutral condi
- Naeimi, Hossein,Rabiei, Khadijeh
-
p. 1102 - 1107
(2012/09/22)
-
- Sonocatalyzed facile and mild one pot synthesis of gem-dichloroaziridine derivatives under alkaline conditions
-
In this research, rapid and efficient preparation of 2,2-dichloro-1,3- diarylaziridines through the reaction of Schiff base compounds with dichlorocarbene yielded in situ from chloroform and sodium hydroxide without any phase transfer catalyst under ultrasonic irradiation is described. The advantages of this reaction are very short reaction times, excellent product yields, simplicity of the method and high purity of products.
- Naeimi, Hossein,Rabiei, Khadijeh
-
experimental part
p. 130 - 135
(2012/04/04)
-
- Ultrasonic-assisted synthesis of 1,3-diaryl-2,2-dichloroaziridine derivatives in the presence of phase-transfer catalyst under low-concentration alkaline conditions
-
In this research, rapid and efficient preparation of 1,3-diaryl-2,2- dichloroaziridines through the reaction of Schiff base compounds with dichlorocarbene yielded in situ in the presence of cetyltrimethylammonium bromide (CTAB) as phase-transfer catalyst
- Naeimi, Hossein,Rabiei, Khadijeh
-
experimental part
p. 1112 - 1117
(2011/11/29)
-
- Mild, convenient and efficient synthesis of novel 2,2-dichloro-1,3- diarylaziridines from Schiff bases by phase transfer CTAB catalysis under low concentration alkaline conditions
-
A mild and efficient method for preparation of novel 2,2-dichloro-1,3- diarylaziridines from Schiff base compounds in the presence of N-cetyl-N,N,N-trimethyl ammonium bromide (CTAB) as phase transfer catalyst has been described. The reaction is dramatical
- Naeimi, Hossein,Rabiei, Khadijeh
-
experimental part
p. 1273 - 1276
(2012/01/06)
-
- Novel synthesis of gem-dichloroaziridines from imines via the KF/Al 2O3-promoted generation of dichlorocarbene from chloroform
-
KF/Al2O3 was found to be an efficient base for the reaction of imines with chloroform in acetonitrile to give gem- dichloroaziridines 2 in moderate to high yields. The KF/ Al2O 3-promoted dichloroaziridination c
- Mihara, Masatoshi,Ishino, Yoshio,Minakata, Satoshi,Komatsu, Mitsuo
-
p. 5320 - 5322
(2007/10/03)
-
- Synthesis of 2,2-Dichloro-1,3-diarylaziridines by Reduction of Trichloroacetophenone Imines
-
2,2-Dichloro-1,3-diarylaziridines, usually obtained by addition of dichlorocarbene to benzylideneanilines, were synthesized by reaction of N-aryl-α,α,α-trichloroacetophenone imines with lithium aluminium hydride in ether.
- Kimpe, Norbert De,Verhe, Roland,Buyck, Laurent De,Schamp, Niceas
-
p. 2079 - 2081
(2007/10/02)
-
- Reactions of Halogenomethanes in the Vapour Phase. Part 5. The Reactions of Imidazolines, Anils, and 1-Methylimidazole with Chloroform at 550 deg C, and a Comparison with their Liquid-Phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base
-
The vapor-phase reactions of imidazolines and anils with chloroform at 550 deg C are compared with their liquid-phase reactions in the presence of hexachloroacetone and base or upon thermolysis with trichloroacetate ion.In the vapour-phase reactions imidazolines, unlike imidazoles, gave non-chlorinated pyrimidines, and 1-methyl-imidazole gave 2-cyanopyrrole and the four 3-chlorocyanopyridines.
- Busby, Reginald E.,Khan, Mohammad A.,Khan, Mohammad R.,Parrick, John,Shaw, C. J. Granville
-
p. 1431 - 1435
(2007/10/02)
-