- Michael-Aldol Double Elimination Cascade to Make Pyridines: Use of Chromone for the Synthesis of Indolizines
-
A domino Michael-aldol double elimination route to indolizines having two different acyl groups at the C5 and C7 positions is described where chromone is employed as a two-carbon unit for the synthesis of a pyridine moiety for the first time. Various analogues were readily accessed in good yields under metal-free and eco-friendly conditions. Further manipulation of the resulting products allowed entry to novel indolizine-heterocycle adducts, which are difficult to access by other methods.
- Joshi, Dirgha Raj,Kim, Ikyon
-
-
Read Online
- Synthesis of 3,3-Dihalogenated 2-Aminochromanones via Tandem Dihalogenation and Cyclization of o-Hydroxyarylenaminones with NXS (X = Cl or Br)
-
An unprecedented method for the synthesis of dichlorinated and dibrominated 2-amino-substituted chromanones is developed by employing enaminones and NCS/NBS as starting materials under microwave irradiation. The reactions proceed quickly to deliver produc
- Luo, Tian,Wu, Haozhi,Liao, Li-Hua,Wan, Jie-Ping,Liu, Yunyun
-
p. 15785 - 15791
(2021/11/01)
-
- X-ray diffraction and VT-NMR studies of (E)-3-(piperidinyl)-1-(2′-hydroxyphenyl)-prop-2-en-1-one
-
A series of 1-aryl-3-(cyclicamino)-prop-2-en-1-one analogs was synthesized from commercial acetophenones in 2 or 3 steps. Compound 6, (E)-3-(piperidinyl)-1-(2′-hydroxyphenyl)-prop-2-en-1-one, exhibited the unique shape and intensity of the Csp2
- Choi, Seunghyun,Kim, Yunhye,Park, Bernie Byeonghoon,Park, Suzie,Park, Jonghyun,Ok, Kiwon,Koo, Jaehyung,Jung, Yong Woo,Jeon, Young Ho,Lee, Eun Hee,Lee, Ken S.,Byun, Youngjoo
-
p. 600 - 605
(2015/02/19)
-
- Benzopyrans: Part XIX - Reactions of 3-Acetyl- and 3-Acetyl-2-methyl-4-oxo-4H-benzopyrans with Nitrogen Nucleophiles
-
3-Acetyl-4-oxo-4H-benzopyran (1a) gives with piperidine the enaminoketone (2); with phenylhydrazine a mixture of the pyrazoles (5a and 7a, R'=Ph); and with hydroxylamine the nitrile (12) and isoxazole (13a) under two different conditions.Like 1a, the chromenone (1b) also behaves as a Michael acceptor towards hydrazine and hydroxylamine to produce the pyrazoles (7b, R'=H, Ph) and isoxazole (13b), respectively.Guanidine forms the pyrimidine (17a) with 1a, but 18b with 1b.
- Ghosh, Chandra Kanta,Pal, Chandana,Bhattacharyya, Atanu
-
p. 914 - 917
(2007/10/02)
-
- Hetericyclic Systems. Part 14. Condensation Reactions of 2-(4-Oxo-4H-1-benzopyran-3-yl)-1,3-dioxolane
-
Nitrogen nucleophiles under 1,4-addition with the title acetal (4; R=H, Me, and Cl) to give an intermediate that ultimately produces in most cases the same product as is obtained from the corresponding aldehyde (3) under similar conditions.Thus, compound
- Ghosh, Chandra Kanta,Bandyopadhyay, Chandrakanta,Morin, Christophe
-
p. 1989 - 1994
(2007/10/02)
-