- A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil
-
A new synthesis of antihyperlipoproteinemic agent 2,2-dimethyl-5-(2,5-dimethylphenoxy) pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β-lactone 6, prepared from cycloaddition of 3-(2,5-dimethylphenoxy) propanal with dimethylketene.The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industral scale of production.Key Words Gemfibrozil; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid; Dimethylketene; cycloaddition; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone.
- Wang, Hui-Po,Lee, On,Fan, Chin-Tsai,Lee, Lain-Tze
-
p. 569 - 572
(2007/10/02)
-
- γ-Substituted Butyrolactones from Acrolein and Carbonyl Compounds
-
The lithiation of 3-chloropropanal diethyl acetal (easily prepared from acrolein) at -78 deg C with lithium naphthalenide followed by reaction with various carbonyl compounds, and final oxidation with m-chloroperbenzoic acid leads to γ-susbstituted butyrolactones.
- Barluenga, Jose,Fernandez, Jose R.,Yus, Miguel
-
p. 1534 - 1535
(2007/10/02)
-