Synthesis and biological evaluation of 4(5)-(6-alkylpyridin-2-yl)imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors
A series of 4(5)-(6-alkylpyridin-2-yl)imidazoles 13a-p, 17a, and 17b have been synthesized and evaluated for ALK5 inhibitory activity in an enzyme assay and in cell-based luciferase reporter assays. The quinoxalinyl analogue 13e inhibited ALK5 phosphoryla
Kim, Dae-Kee,Jang, Yoojeung,Ho, Soon Lee,Park, Hyun-Ju,Yoo, Jakyung
p. 3143 - 3147
(2008/02/08)
2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
Compounds of the formula: wherein R1, R2, R3, A1 and A2 are as defined herein, which are used advantageously in inhibiting the TGF-β and/or activin signaling pathway in mammals.
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Page/Page column 8
(2008/06/13)
Pyridinylimidazoles
Compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R1, R2 and R3 represent various functional groups, and one of X1 and X2 is N and the other is NR10; and their
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(2008/06/13)
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