- The solid phase synthesis of tri-substituted indoles
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The palladium-catalyzed solid phase synthesis of tri-substituted indoles is described. The synthesis incorporates three independently variable groups and is ideally suited for the preparation of combinatorial libraries.
- Collini, Michael D.,Ellingboe, John W.
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Read Online
- A significant enhancement of water vapour uptake at low pressure by amine-functionalization of UiO-67
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The functionalization of UiO-67 with -NH2 groups enhances CO2 and CH4 adsorption at 1 bar and 298 K and positively influences the framework's interaction with water as evidenced by the significant enhancement of water vapo
- Ko, Nakeun,Hong, Jisu,Sung, Siyoung,Cordova, Kyle E.,Park, Hye Jeong,Yang, Jin Kuk,Kim, Jaheon
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Read Online
- Thermal decomposition pathways of nitro-functionalized metal-organic frameworks
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The decomposition behavior of high energy metal-organic frameworks (MOFs) with extensive nitration is disclosed. In contrast to the detonation behavior observed in molecular energetic compounds, deflagration transforms cubic MOFs into anisotropic carbon s
- McDonald, Kyle A.,Ko, Nakeun,Noh, Kyungkyou,Bennion, Jonathan C.,Kim, Jaheon,Matzger, Adam J.
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Read Online
- Modulating Guest Uptake in Core–Shell MOFs with Visible Light
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A two-component core–shell UiO-68 type metal–organic framework (MOF) with a nonfunctionalized interior for efficient guest uptake and storage and a thin light-responsive outer shell was prepared by initial solvothermal MOF synthesis followed by solvent-as
- Mutruc, Dragos,Goulet-Hanssens, Alexis,Fairman, Sam,Wahl, Sebastian,Zimathies, Annett,Knie, Christopher,Hecht, Stefan
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supporting information
p. 12862 - 12867
(2019/08/08)
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- Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions
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Versatile and practical Ag/Cu-mediated decarboxylative halogenation between readily available aryl carboxylic acids and abundant NaX (X = I, Br, Cl) has been achieved under aerobic conditions in moderate to good yields. The halodecarboxylation is shown to be an effective strategy for S-containing heteroaromatic carboxylic acid and benzoic acids with nitro, chloro and methoxyl substituents at the ortho position. A gram-scale reaction and a three-step procedure to synthesize iniparib have been performed to evaluate the practicality of this protocol. A preliminary mechanistic investigation indicates that Cu plays a vital role and a radical pathway is involved in the transformation.
- Fu, Zhengjiang,Jiang, Ligao,Zuo, Qianming,Li, Zhaojie,Liu, Yanzhu,Wei, Zhenhong,Cai, Hu
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p. 5416 - 5421
(2018/08/12)
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- BENZAMIDE DERIVATIVE WITH ANTICANCER ACTIVITY AND PREPARATION METHOD AND USE THEREOF
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Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula (I) are as set out
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Paragraph 0081; 0082
(2013/09/12)
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- Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5- carboxylic acid and structural development to increase potency
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We have reported that retinoid X receptor (RXR) partial agonist 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5- carboxylic acid (CBt-PMN, 4a) shows a significant antidiabetes effect in the KK-Ay type 2 diabetes model
- Ohsawa, Fuminori,Yamada, Shoya,Yakushiji, Nobumasa,Shinozaki, Ryosuke,Nakayama, Mariko,Kawata, Kohei,Hagaya, Manabu,Kobayashi, Toshiki,Kohara, Kazutaka,Furusawa, Yuuki,Fujiwara, Chisa,Ohta, Yui,Makishima, Makoto,Naitou, Hirotaka,Tai, Akihiro,Yoshikawa, Yutaka,Yasui, Hiroyuki,Kakuta, Hiroki
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p. 1865 - 1877
(2013/05/09)
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- Combined study of anion recognition by a carbazole-based neutral tripodal receptor in a competitive environment
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Anion recognition studies have been carried out on a series of neutral synthetic receptors in which carbazole-2-carboxamide has been used as building block. Different ligands which include one to three carbazole units in their structure have been prepared
- Curiel, David,Sanchez, Guzman,Ramirez De Arellano, Carmen,Tarraga, Alberto,Molina, Pedro
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experimental part
p. 1896 - 1904
(2012/04/23)
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- NOVEL CC-1065 ANALOGS AND THEIR CONJUGATES
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This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
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Page/Page column 140
(2010/06/17)
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- Synthesis of new crosslinkable co-polymers containing a push-pull zinc porphyrin for non-linear optical applications
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In this paper, the synthesis of a crosslinkable co-polymer containing new push-pull arylethynyl zinc porphyrins is described. The synthesis of porphyrin chromophores, analogous to Therien's porphyrin (J. Am. Chem. Soc. 1996, 118, 1497-1503) functionalized
- Monnereau, Cyrille,Blart, Errol,Montembault, Véronique,Fontaine, Laurent,Odobel, Fabrice
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p. 10113 - 10121
(2007/10/03)
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- NOVEL MCH RECEPTOR ANTAGONISTS
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The present invention relates to a melanin concentrating hormone antagonist compound of formula I: or a pharmaceutically acceptable salt thereof, useful for the treamtment useful fog treating Type H diabetes and/or obesity.
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Page/Page column 67-68
(2010/02/11)
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