- Synthesis method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid
-
The invention belongs to medical intermediates, and particularly relates to a synthesis method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid. The 6-fluoro-3-hydroxypyrazine-2-carboxylic acid is prepared by taking a compound A, namely 3-aminopyrazine-2-carboxylic acid methyl ester as an initial raw material through five-step reaction, the synthetic method of the 6-fluoro-3-hydroxypyrazine-2-carboxylic acid is provided, a synthetic route is provided for the synthetic method of the 6-fluoro-3-hydroxypyrazine-2-carboxylic acid, the synthesis method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid provided by the invention is reasonable in design, simple to operate and easy to control, and meanwhile, the product obtained by the invention is relatively high in yield.
- -
-
Paragraph 0005; 0013-0015
(2021/07/21)
-
- Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof
-
Pyrazine derivatives represented by general formula [1]: 1wherein the variables are as defined in the specification, or salts thereof have an excellent antiviral activity and are useful as a therapeutic agent for treating viral infections. Further, fluoropyrazine-carboxamide derivatives represented by general formula [2]: 2wherein the variables are as defined in the specification, or salts thereof are useful as an intermediate for production of the compounds of general formula [1], and as an intermediate for production of the fluoropyrazine-carboxamide derivatives of which one typical example is 6-fluoro-3-hyroxy-2-pyrazine-carboxamide having an antiviral activity.
- -
-
-