- PROCESS FOR THE PREPARATION OF CARBOPROST AND ITS TROMETHAMINE SALT
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The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silicagel chromatography and the salt formation is carried out by using solid tromethamine base.
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- IMPROVED METHOD FOR THE WITTIG REACTION IN THE PREPARATION OF CARBOPROST
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A process for the preparation of carboprost methyl ester (figure (10)).
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Page/Page column 16; 21
(2008/12/07)
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- 8β,12α,15β-PGF2 β Compounds
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This invention is a group of 8-beta, 12-alpha-PG2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
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