Amidino benzimidazole inhibitors of bacterial two-component systems
Amidino benzimidazoles have been identified as inhibitors of the bacterial KinA/Spo0F two-component system (TCS). Many of these inhibitors exhibit good in vitro antibacterial activity against a variety of susceptible and resistant Gram-positive organisms.
Weidner-Wells, Michele A.,Ohemeng, Kwasi A.,Nguyen, Van N.,Fraga-Spano, Stephanie,Macielag, Mark J.,Werblood, Harvey M.,Foleno, Barbara D.,Webb, Glenda C.,Barrett, John F.,Hlasta, Dennis J.