Formal synthesis of brivaracetam: A key to construct the pyrrolidone scaffold using Pd-catalyzed oxidative cyclization and ring-closing metathesis reaction
A short and efficient synthetic approach for brivaracetam has been accomplished via two different routes which utilize Pd-catalyzed oxidative cyclization and ring-closing metathesis (RCM) as the key reaction. These two routes are novel, simple, scalable and rely on (E)-pent-2-en-1-ol and valeraldehyde as a commercially available starting material to yield brivaracetam with good overall yield.
Chavan, Subhash P.,Kawale, Sanket A.,Chavan, Prakash N.
(2019/11/11)
PROCESS FOR PREPARING BRIVARACETAM
The present invention relates to a new process for preparing brivaracetam. (Ib)
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Page/Page column 7-8
(2017/06/23)
CONTINUOUS PROCESS FOR PREPARING BRIVARACETAM
The present invention relates to a continuous flow process for preparing brivaracetam.
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Page/Page column 10
(2017/09/02)
NEW HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS
The present invention relates to new compounds, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
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Page/Page column 61-62
(2008/12/08)
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