- Synthesis and purification of [2-13C]-5-fluorouracil
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[2-13C]-5-Fluoropyrimidine-2,4(1H,3H)-dione ([2- 13C]-5-fluorouracil or [2-13C]-5-FU) is a potential diagnostic agent for measuring 5-FU-induced toxicity in cancer patients. It was prepared and purified with isotopic and chemical purity of>99% on a multigram scale in a two-step synthesis from [13C]-urea. Preparative separation of [2-13C]-FU and [2-13C]-uracil was carried out by automated medium pressure silica gel column chromatography. The method is applicable to a broader range of 5-FU isotopic analogs derived from labeled uracil. Copyright 2011 John Wiley & Sons, Ltd. [2- 13C]-5-Fluoropyrimidine-2,4(1H,3H)-dione ([2-13C]-5- fluorouracil or [2-13C]-5-FU) is a potential diagnostic agent for measuring 5-FU-induced toxicity in cancer patients. It was prepared and purified with isotopic and chemical purity of >99% on a multigram scale in a two-step synthesis from [13C]-urea. Preparative separation of [2- 13C]-FU and [2-13C]-urea was carried out by medium pressure automated silica gel column chromatography. The method is applicable to a broader range of 5-FU isotopic analogs derived from labeled uracil. Copyright
- Rangwala, Huzaifa S.,Giraldes, John W.,Gurvich, Vadim J.
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- SPECIFIC REARRANGEMENTS OF DIHYDROPYRIMIDINEDIONES TO PYRIDONES VIA DIAZACYCLOOCTATETRAENE INTERMEDIATES
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The rearrangement of a uracil-alkyne photoadduct has been studied by (13)C- and (15)N-labeling experiments.A diazacyclooctatetraene intermediate suggested as an intermediate from these labeling studies has been independently prepared and shown to undergo rapid rearrangement to a pyridone.
- Kaminski, Victor V.,Swenton, John S.,Cottrell, Charles E.
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- Synthesis of 13C-labelled compounds having a urea unit, and observation of 13C-isotope effect in their infrared spectra
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Various drugs and nucleic acids containing a urea unit were synthesized from [13C]urea. The 13C-isotope effect in the infrared spectra of these compounds was examined.
- Iida, Katsumi,Chiyoda, Takeshi,Hirasawa, Ryo,Iwata, Akiko,Kajiwara, Masahiro
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