N-Methylimidazole-mediated synthesis of aryl alkyl ethers under microwave irradiation and solvent free conditions
A microwave-assisted three-component reaction was established for the synthesis of aryl alkyl ethers. The reaction was performed under solvent-free conditions in the presence of N-methylimidazole and dialkyl acetylene-dicarboxylate to furnish a novel approach to O-alkylation of phenol derivatives in high yield.
Indium(0)-mediated Csp 3-S/O cross-coupling approach towards the regioselective alkylation of α-enolic esters/dithioesters: A mechanistic Insight
We have reported an indium(0)-mediated Csp3-S/O cross-coupling approach that leads to the highly regioselective alkylation of α-enolic acetate/dithioacetate systems. This hetero cross-coupling reaction does not require additional co-catalyst or promoter, and the in situ generated organoindium species promotes the reaction by acting as the coupling partner of the α-enolic acetate/dithioacetate substrates. The excellent selectivity for C-, S-, or O-alkylation is solely dependent on the nucleophilic behavior of α-enolic acetate/dithioacetate systems. These results were further supported by DFT calculations of the relative electronic energies of the substrates and products as well as the activation barriers of the respective transformations.
Chowdhury, Sushobhan,Chanda, Tanmoy,Gupta, Ashutosh,Koley, Suvajit,Ramulu, B. Janaki,Jones, Raymond C. F.,Singh, Maya Shankar
supporting information
p. 2964 - 2971
(2014/05/20)
Research on antitumor agents. XI. Formation of pyrimidine derivatives from 4 hydroxy and 4 ethoxycoumarins
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Takagi,Hubert Habart
p. 681 - 683
(2007/10/08)
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