- Synthesis of 1-aroyl(1-arylsulfonyl)-4-bis(trifluoromethyl)alkyl semicarbazides as potential physiologically active compounds
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1,1-Bis(trifluoromethyl)alkyl isocyanates obtained from perfluoroisobutene (PFIB) react with aroyl(arylsulfonyl)hydrazines. Twenty eight prospective biologically active polyfluorinated 1,4-substituted semicarbazides were synthesized. The structure of each
- Luzina, Elena L.,Popov, Anatoliy V.
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- Synthesis and anticancer activity of N-bis(trifluoromethyl)alkyl-N′-thiazolyl and N-bis(trifluoromethyl)alkyl-N′-benzothiazolyl ureas
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A number of N-bis(trifluoromethyl)alkyl-N′-thiazolyl and -benzothiazolyl ureas have been synthesized and evaluated for their in vitro antiproliferative activities against the human cancer cell lines at the National Cancer Institute (NCI, USA). The activity was shown for compounds 8a,c and 9a-c. The most sensitive cell lines relative to the tested compounds are: 8c PC-3 (prostate cancer, log GI50 -7.10), 9c SNB-75 (CNS cancer, log GI50 -5.84), 9b UO-31 (renal cancer, log GI50 -5.66), and SR (leukemia, log GI50 -5.44) human cancer cells.
- Luzina, Elena L.,Popov, Anatoliy V.
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experimental part
p. 4944 - 4953
(2010/02/27)
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- Iridium-catalyzed reactions of trifluoromethylated compounds with alkenes: A Csp3-H bond activation α to the trifluoromethyl group
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(Chemical Equation Presented) Catalytic convenience: The use of iridium or ruthenium catalysts for Csp3-H bond activation has led to the addition reaction of trifluoromethylated compounds to alkenes (see scheme). This atom-economical reaction o
- Guo, Yong,Zhao, Xiaming,Zhang, Dazhi,Murahashi, Shun-Ichi
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supporting information; experimental part
p. 2047 - 2049
(2009/07/25)
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- Exchange reactions of organotin and organosilicon compounds with vinylic fluorine
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Compounds carrying reactive fluorine atoms, such as methylphosphonis difluoride and perfluoroisobutene, undergo facile exchange with organosilanes and stannanes.Reactions with protic nucleophiles also yield similar products.To account for the products formed and observed reactivity differences, appropriate mechanisms are proposed.The reactions described herein have considerable synthetic utility.
- Rossman, D. I.,Muller, A. J.
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- CONVERSION OF METHOXYPERFLUOROISOBUTENE TO α-METHYLHEXAFLUOROISOBUTYRIC ACID FLUORIDE BY A PHASE TRANSFER CATALYST
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Methoxyperfluoroisobutene was converted to α-methylhexafluoroisobutyric acid fluoride by a catalytic amount of phase transfer catalyst in quantitative yield.
- Misaki, Susumu
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p. 471 - 475
(2007/10/02)
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