- New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity
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We screened a short series of new chiral diphenylmethane derivatives and identified potent dual PPARα/γ partial agonists. As both enantiomers of the most active compound 1 displayed an unexpected similar transactivation activity, we performed docking expe
- Piemontese, Luca,Cerchia, Carmen,Laghezza, Antonio,Ziccardi, Pamela,Sblano, Sabina,Tortorella, Paolo,Iacobazzi, Vito,Infantino, Vittoria,Convertini, Paolo,Dal Piaz, Fabrizio,Lupo, Angelo,Colantuoni, Vittorio,Lavecchia, Antonio,Loiodice, Fulvio
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p. 379 - 397
(2017/01/12)
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- Structure-activity relationships of bisphenol a analogs at estrogen receptors (ERs): Discovery of an ERα-selective antagonist
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Our multi-template approach for drug discovery, focusing on protein targets with similar fold structures, has yielded lead compounds for various targets. We have also shown that a diphenylmethane skeleton can serve as a surrogate for a steroid skeleton. H
- Maruyama, Keisuke,Nakamura, Masaharu,Tomoshige, Shusuke,Sugita, Kazuyuki,Makishima, Makoto,Hashimoto, Yuichi,Ishikawa, Minoru
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p. 4031 - 4036
(2013/07/19)
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- NOVEL DIAZONAPHTHOQUINONESULFONIC ACID BISPHENOL DERIVATIVE USEFUL IN PHOTO LITHOGRAPHIC SUB MICRON PATTERNING AND A PROCESS FOR PREPARATION THEREOF
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The present invention provides novel diazonaphthoquinonesulfonic acid bisphenol derivatives. More particularly, the present invention relates to photo restive coating comprising alkali-soluble resin, a photoactive compound and a surfactant. The photoresist film prepared has less then one micron. The photoactive compound is soluble or swellable in aqueous alkaline solutions and is diazonaphthoquinonesulfonic bisphenol esters of the general formula (A), wherein DNQ represents a 2-Diazo-1-naphthoquinone-4-sulfonyl, 2-Diazo-1-naphthoquinone-5-sulfonyl, 1-Diazo-2-naphthoquinone-4-sulfonyl groups and R1 R1 represents an alkyl, aryl and substituted aryl groups. The invention also provides a process for coating and imaging the light-sensitive composition.
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- NOVEL DIAZONAPHTHOQUINONESULFONIC ACID BISPHENOL DERIVATIVE USEFUL IN PHOTO LITHOGRAPHIC SUB MICRON PATTERNING AND A PROCESS FOR PREPARATION THEREOF
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The present invention provides novel diazonaphthoquinonesulfonic acid bisphenol derivatives. More particularly, the present invention relates to photo restive coating comprising alkali-soluble resin, a photoactive compound and a surfactant. The photoresist film prepared has less then one micron.The photoactive compound is soluble or swellable in aqueous alkaline solutions and is diazonaphthoquinonesulfonic bisphenol esters of the general formula (A), wherein DNQ represents a 2-Diazo-1-naphthoquinone-4-sulfonyl, 2-Diazo-1- naphthoquinone-5-sulfonyl, 1-Diazo-2-naphthoquinone-4-sulfonyl groups and R1 R1 represents an alkyl, aryl and substituted aryl groups. The invention also provides a process for coating and imaging the light-sensitive composition.
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Page/Page column 14
(2008/12/04)
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- 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1
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We designed and synthesized novel type 1 5α-reductase inhibitors by using 3,3-diphenylpentane skeleton as a substitute for the usual steroid skeleton. 4-(3-(4-(N-Methylacetamido)phenyl)pentan-3-yl)phenyl dibenzylcarbamate (11k) is a competitive 5α-reductase inhibitor with the IC50 value of 0.84 μM.
- Hosoda, Shinnosuke,Hashimoto, Yuichi
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p. 5414 - 5418
(2008/02/13)
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- Processes for producing aromatic polycarbonate oligomer and aromatic polycarbonate
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A process for producing continuously an aromatic polycarbonate oligomer by reacting an aromatic dihydroxy compound and an alkali metal base or an alkaline earth metal base with a carbonyl halide compound comprises: (1) feeding continuously to a tank reactor an aromatic dihydroxy compound, water, a molecular weight controlling agent, a polymerization catalyst, a carbonyl halide compound, and an organic solvent, and an alkali metal base or an alkaline earth metal base in an amount of 1.15-1.6 equivalents based on the aromatic dihydroxy compound, (2) carrying out the reaction with a residence time as defined by the following formula, where X is an amount of the polymerization catalyst in terms of mole % based on the amount of mole of the aromatic dihydroxy compound fed per unit time, and Y is a residence time (min.), and (3) continuously withdrawing the reaction mixture from the tank reactor to obtain an aromatic polycarbonate oligomer having a number average molecular weight of 1,000-10,000. An aromatic polycarbonate is produced by polycondensation of the aromatic polycarbonate oligomer.
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- Processes for bisphenols
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A process for the preparation of gem-bis(hydroxyaryl)alkanes which comprises the reaction of a ketone, a hydroxyarene and an alkylhalosilane.
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