- A novel method for preparing isocyanides from N-substituted formamides with chlorophosphate compounds
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Treatment of N-substituted formamides with chlorophosphate compounds such as PhOPOCl2, EtOPOCl2, Me2NPOCl2, and (PhO)2POCl and tertiary amines such as triethylamine, pyridine, and N,N-diisopropylethylamine produced the corresponding isocyanides in high yields. This method can be used to prepare various alkyl and aryl isocyanides. Georg Thieme Verlag Stuttgart · New York.
- Kobayashi, Genki,Saito, Tateo,Kitano, Yoshikazu
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experimental part
p. 3225 - 3234
(2011/11/30)
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- Synthesis of 4-hydroxy-3-quinolinecarboxylic acid derivatives by a condensation/cyclization sequence between o-isocyanobenzoates and magnesium enolates
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Addition of magnesium ester and amide enolates, generated using an excess amount of a magnesium amide (from diisopropylamine and ethylmagnesium bromide), to o-isocyanobenzoates affords 4-hydroxy-3-quinolinecarboxylic esters and amides by a tandem Claisen-type condensation/cyclization sequence.
- Kobayashi, Kazuhiro,Nakashima, Toshio,Mano, Masaaki,Morikawa, Osamu,Konishi, Hisatoshi
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p. 602 - 603
(2007/10/03)
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