- Pyridyl Radical Cation for C?H Amination of Arenes
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Electron-transfer photocatalysis provides access to the elusive and unprecedented N-pyridyl radical cation from selected N-substituted pyridinium reagents. The resulting C(sp2)?H functionalization of (hetero)arenes furnishes versatile intermediates for the development of valuable aminated aryl scaffolds. Mechanistic studies that include the first spectroscopic evidence of a spin-trapped N-pyridyl radical adduct implicate SET-triggered, pseudo-mesolytic cleavage of the N?X pyridinium reagents mediated by visible light.
- R?ssler, Simon L.,Jelier, Benson J.,Tripet, Pascal F.,Shemet, Andrej,Jeschke, Gunnar,Togni, Antonio,Carreira, Erick M.
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supporting information
p. 526 - 531
(2019/01/04)
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- Rational design of MOFs constructed from modified aromatic amino acids
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Three Phe and Tyr derivatives, 2-amino-3-(4-aminophenyl)-propionic acid (AAP), 3E-[5-(2-amino-2-carboxyethyl)-2-methoxyphenyl]-acrylic acid (AMPA) and 3-(4-aminophenyl)-2-(carboxymethyl-amino)-propionic acid (ACP) have been chosen as the ligands to constr
- Xie, Yu,Yu, Zhaopeng,Huang, Xiaoying,Wang, Zhiyong,Niu, Liwen,Teng, Maikun,Li, Jing
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p. 9399 - 9405
(2008/09/21)
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- Method for preparing enantiomeric forms of amino alkylaminophenyl propanoic acid
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A process for preparing an enantiomeric form of 2-amino-3-(4-alkylaminophenyl)-propanoic acid of formula (I) or a salt thereof: STR1 in which Alk represents an alkyl radical containing 1 to 2 carbon atoms, from (L)-phenylalanine to obtain the (S)-enantiomer of 2-amino-3-(4-alkylaminophenyl)-propanoic acid, or from (D)-phenylalanine to obtain the (R)-enantiomer of 2-amino-3-(4-alkylaminophenyl)propanoic acid.
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- Enzymes immobilisees. 14 : Immobilisation de la chymotrypsine prealablement protegee par un inhibiteur macromoleculaire synthetique
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A new water-soluble acrylic copolymer 13, with spacer-arms bearing N-(4-phenylbutyl)amido groups, was sythesized and was efficiently used to protect α-chymotrypsin during immobilization of the latter on Acaprosuc, an insoluble cross-linked polyacrylic gel whose side-chains end with reactive N-siccinimidyl ester groups.The insoluble chymotrypsin/Acaprosuc conjugates prepared in the presence of the polyinhibitor 13 were twice as active towards heamoglobin, and 2 to 4 times as active towards ATEE, as the corresponding conjugates prepared in the absence of the polyinhibitor 13.These results represent a generalization of the enzyme protection/immobilization/deprotection method which was developed in our laboratory some years ago in the particular case of trypsin.
- Brown, Eric,Loriot, Michel
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p. 481 - 489
(2007/10/02)
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- Amino acids and esters thereof useful as antihypertensive agents
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A compound of the formula STR1 possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
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