Synthesis and biological evaluation of non-polyene analogs of amphotericin B
Synthesis of the first analog of a polyene macrolide antibiotic containing a rigid, non-polyene backbone has been accomplished. The sterol recognition surface of amphotericin B has been modified in an effort to better understand the role of the polyene backbone. Its antifungal activity is reduced significantly compared with amphotericin B.
Rogers, Bruce N.,Selsted, Michael E.,Rychnovsky, Scott D.