- γ-hydroxypropylation of 2,6-dialkyl(aryl)phenols with allyl alcohol and its derivatives
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The composition of the products of the reaction of 2,6-disubstituted phenols with allyl alcohol and its derivatives in an alkaline medium was investigated, the conditions for carrying out the reaction with the predominant formation of 4-(3-hydroxypropyl)-2,6-dialkyl(aryl)phenols were found, and its mechanism was suggested. The reaction was examined on an industrial scale. An important result is the practical demonstration of alkaline catalysis performed under homogeneous conditions with participation of phenols, when the used alkaline catalyst is recovered in the process without the formation of waste waters. Pleiades Publishing, Ltd., 2010.
- Krysin,Khalikova,Khlebnikova,Nogina,Mamatyuk
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experimental part
p. 2290 - 2297
(2011/04/14)
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- Synthesis of 4-(ω-hydroxyalkyl)-2,6-di-tert-butylphenols and the properties of related sulfides
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Reaction of 2,6-di-tert-butylphenol with aliphatic linear and branched diols in an alkaline medium at a temperature of 180-220°C leads to the formation of 4-(ω-hydroxyalkyl)-2,6-di-tert-butylphenols. The increase in the product yield and reducing the reaction temperature was reached at the catalysis of this reaction with zinc oxide. The structure of the diphenylalkane derivatives generated in side reaction was proved and the structural influence of the length of the aliphatic residue on the antioxidant effectiveness of the sulfides derived from the corresponding hydroxyalkylphenols was examined.
- Krysin,Pustovskikh,Koptyug
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experimental part
p. 2001 - 2006
(2011/02/18)
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- Synthesis of benzotriazole monomer
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The synthesis of benzotriazole monomers and the use of the benzotriazole monomers and one or more other monomers to prepare ultraviolet (UV) light absorbing polymer compositions. The synthetic methods described in this application provide a significant improvement over the previous methods used to prepare benzotriazole monomers.
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Page/Page column 15
(2010/12/26)
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- Synthesis and antioxidant properties of sodium S-[3-(hydroxyaryl)propyl] thiosulfates and [3-(hydroxyaryl)propane]-1-sulfonates
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Sodium S-[3-(hydroxyaryl)propyl] thiosulfates and [3-(hydroxyaryl)propane]- 1-sulfonates with various spatial hindrance of their phenolic OH groups were synthesized from dialkylphenols via a number of intermediate products. On a model reaction of oxidation of methyl oleate in aqueous sodium dodecyl sulfate, the rate constants of the interaction of the synthesized compounds with lipoperoxide radicals were determined.
- Oleynik,Kuprina,Pevneva,Markov,Kandalintseva,Prosenko,Grigor'ev
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p. 1135 - 1143
(2008/09/17)
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- New series of aryloxypropanolamines with both human β3-adrenoceptor agonistic activity and free radical scavenging properties
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A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the β3-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-, di-tert-butylphenolyl- or methoxyindolyl-type. Some of the products possessed both the expected activities.
- Aubriot, Silvere,Nicolle, Edwige,Lattier, Mireille,Morel, Cecile,Cao, Wenhong,Daniel, Kiefer W.,Collins, Sheila,Leclerc, Gerard,Faure, Patrice
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p. 209 - 212
(2007/10/03)
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- New BHT ether compounds and their use as hypolipidemic and antiatherosclerotic drugs
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Pharmaceutically-active BHT-omega pyridyl ethers of the formula selected from BHT-omega-pyridyl ether compounds of the formula: STR1 wherein m=1,3 for m=1, Σ=6-9 for m=3, Σ=5-11 Sum (Σ)=[m+n+1 (for oxygen)] wherein the bond between the two carbon atoms of the (CH2)n moiety most closely adjacent the pyridine ring is a single, double, or triple bond, and pharmaceutically-acceptable acid addition salts thereof, pharmaceutical compositions thereof, and a method of combating lipidemia and atherosclerosis therewith, are disclosed.
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- 2'-hydroxy-5'-(hydroxyalkyl)phenyl-2H-benzotriazoles
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The compounds 2'-hydroxy-5'-(hydroxyalkyl)phenyl-2H-benzotriazoles are useful as intermediate alcohols in the preparation of corresponding 2'-hydroxy-5'-acrylyloxyphenyl-2H-benzotriazole monomers, which in turn are copolymerizable with ethylenically unsaturated monomers, particularly acrylic monomers, to impart ultraviolet absorbing properties to the resulting copolymers.
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- Alkylation of 2,6-di-tert-alkylphenols with alkanediols
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There is a process disclosed for alkylating the nucleus of a phenol, said process comprising reacting an α, ωalkanediol containing from 3 to 8 carbon atoms with a phenol having an unsubstituted nuclear position para to the phenolic hydroxyl group; said ph
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