- 2,6-bis(diethanolamine)-4,8-dipiperidine-pyrimidine-[5,4-d]pyrimidine synthetic method
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The invention discloses a 2,6-bis(diethanolamine)-4,8-dipiperidine-pyrimidine-[5,4-d]pyrimidine synthetic method. According to the invention, orotic acid is taken as an initial raw material, which iscompletely different with the raw material in the prior art, usage of diethanolamine is omitted, so that an end product as a uniform target product is obtained, the target product is shown as a formula I, and at the same time, the end product yield is increased so that the end product is economic and practical on industrial production.
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Paragraph 0030; 0032-0033
(2018/11/22)
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- Preparation method of 5-chloro-6-(chloromethyl)-2,4-(1H,3H)-pyrimidinedione
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The patent provides a preparation method of 5-chloro-6-(chloromethyl)-2,4-(1H,3H)-pyrimidinedione. Orotic acid, which is used as a starting material, undergoes alpha-hydrogen chlorination; then, carboxyl is directly reduced to hydroxymethyl; and a chlorination replacement reaction is carried out. Through the three-step reactions, the target product is obtained. The preparation method of the invention is simple to operate, has stable process, has high yield, is low-cost, and is suitable for industrial production.
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Page/Page column 7
(2017/09/13)
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