- Crystalline form doripenem monohydrate and preparation method thereof
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The present invention relates to a method for preparing doripenem monohydrate, and more particularly, to a method for preparing doripenem monohydrate produced through the steps of: conducting a deprotecting reaction by reacting doripenem-PNB with a zinc powder in a mixture solution including an organic solvent and an aqueous phosphate solution (step 1); removing phosphate from the product of step 1 (step 2); and crystallizing the product of step 2 using a solvent for crystallization to crystallize the doripenem monohydrate (step 3). According to the method for preparing the doripenem monohydrate, the method can be conducted at room temperature and at a moderate atmospheric pressure without using an expensive metal catalyst and special equipment. Thus, the method is economical and safe, and the doripenem monohydrate can be obtained at a high yield. Accordingly, the preparation method of the present invention can be usefully applied in an industrial field related to doripenem monohydrate.
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Paragraph 0047; 0048; 0049; 0050
(2016/10/09)
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