- Synthesis of 5-aryloxazolidines via 1,3-dipolar cycloaddition reaction of a non-stabilized azomethine ylide with aromatic aldehydes
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The 1,3-dipolar cycloaddition reaction of a non-stabilized azomethine ylide 4a, formed in situ from N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine 5 and a catalytic amount of trifluoroacetic acid, with aromatic aldehydes 3 gives rise to N-benzyl-5-
- Ryan, John H.,Spiccia, Nadia,Wong, Leon S.-M.,Holmes, Andrew B.
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- Synthesis of indazole-N-oxides via the 1,7-electrocyclization of azomethine ylides
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The first examples of the 1,7-electrocyclization of azomethine ylides onto a nitro group, to give benz-1,2,6-oxadiazepine intermediates are reported. Subsequent ring contraction results in the formation of indazole-N-oxides. Graphical Abstract
- Nyerges, Miklós,Virányi, Andrea,Zhang, Weimin,Groundwater, Paul W.,Blaskó, Gábor,Toke, László
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p. 9937 - 9944
(2007/10/03)
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- Synthesis of indazole-N-oxides via the 1,7-electrocyclisation of azomethine ylides
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The first example of the 1,7-electrocyclisation of a non-stabilised azomethine ylide, e.g. 2, onto a nitro group, to give a 1,2,6-oxadiazepine intermediate, e.g. 4, is reported. Subsequent ring contraction results in the formation of the indazole-N-oxides 5, 12, and 14.
- Nyerges, Miklós,Fejes, Imre,Virányi, Andrea,Groundwater, Paul W.,Toke, László
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p. 5081 - 5083
(2007/10/03)
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- A new and convenient synthesis of 1-aryl-2-dimethylaminoethanols
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An efficient two-step synthesis of 1-aryl-2-dimethylamnoethanols 4 is described, consisting of oxazolidine 3 generation from the cycloaddition of an azomethine ylide to an aldehyde, followed by reductive ring-opening.
- Nyerges,Fejes,Virányi,Groundwater,T?ke
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p. 1479 - 1482
(2007/10/03)
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