- Fluorination of aryl boronic acids using acetyl hypofluorite made directly from diluted fluorine
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Aryl boronic acids or pinacol esters containing EDG were converted in good yields and fast reactions to the corresponding aryl fluorides using the readily obtainable solutions of AcOF. In reactions with aryl boronic acids containing EWG at the para position, there are two competing forces: one directing the fluorination to take place ortho to the boronic acid and the other, toward an ipso substitution. With EWG meta to the boronic acid, substitution ipso to the boron moiety takes place in good yields.
- Vints, Inna,Gatenyo, Julia,Rozen, Shlomo
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p. 11794 - 11797
(2014/01/06)
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- Facile conversion of arenediazonium salts to the corresponding fluoroarenes using boron trifluoride diethyl ether complex
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The conversion of various arenediazonium salts 1 to the corresponding fluoroarenes 2 has been achieved in good yields under mild conditions in boron trifluoride diethyl ether complex.
- Shinhama,Aki,Furuta,Minamikawa
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p. 1577 - 1582
(2007/10/02)
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- A process for the preparation of o-chlorofluorobenzene
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ο-Chlorofluorobenzene is prepared from 1,2,3-trichlorobenzene by partial fluorine exchange to a mixture of 2,6-dichlorofluorobenzene and 2,3-dichlorofluorobenzene followed by selective reduction to a mixture of fluorobenzene, ο-chlorofluorobenzene and 2,3-dichlorofluorobenzene. Each of the components of this latter mixture can be separated by a relatively easy distillation, and each has value as an intermediate in the manufacture of other valuable organic chemicals.
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- AROMATIC FLUORINE CHEMISTRY. PART 5. PREPARATION OF 2,6-DIFLUOROANILINE AND 1,2-DIFLUOROBENZENE
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The preparation of 2,6-difluoroaniline and 1,2-difluorobenzene from 1,2,3-trichlorobenzene is described.An isomeric mixture of 1-chloro-2,3-difluorobenzene and 2-chloro-1,3-difluorobenzene is obtained from KF exchange on 1,2,3-trichlorobenzene.Selective dechlorination of 1-chloro-2,3-difluorobenzene with H2 and Pd/C catalyst gives 1,2-difluorobenzene. 2,6-difluoroaniline is obtained via ammonolysis of 2-chloro-1,3-difluorobenzene.
- Pews, R. Garth,Gall, James A.
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p. 379 - 386
(2007/10/02)
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