Synthesis of Naphthoindolizine-6,11-dione Derivatives by Iodine Oxidation of 2-Alkyl-1,4-naphthoquinones in the Presence of Substituted Pyridines
Iodine oxidation of 2-alkyl-1,4-naphthoquinones (1) in the presence of substituted pyridines (2) afforded naphthoindolizine-6,11-dione derivatives (3). Other oxidant systems (MnO2/I- or Fe(ClO4)3/I2) can be used and 2-alkylbenzoquinones