- Synthesis and antiproliferative activity of new 1,2,3-triazole/flavone hybrid heterocycles against human cancer cell lines
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A series of new 1,2,3-triazole/flavone hybrid heterocycles were synthesized from 6-amino flavone via key intermediate N-propargyl flavone 6 by adopting the Sharpless Click reaction. Copper(I) catalyzed 1,3-dipolar cycloaddition reaction that gave products in high yields. All the synthesized compounds were screened for their in vitro antiproliferative activity against four human cancer cell lines, HeLa (cervical cancer cell line), MIA PaCa (pancreatic cancer cell line), MDA-MB-231 (breast cancer cell line), and IMR 32 (neuroblastoma cancer cell line). Compounds 7a, 7b, 7d, 7g (GI50 = 0.01–0.68 μM) demonstrated promising antiproliferative activity.
- Sowjanya,Jayaprakash Rao,Murthy
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p. 1864 - 1871
(2017/09/25)
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- Synthesis and microbial activity of new 1,4-benzothiazines bearing paracetamol moiety
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5-Acetamido-2-hydroxyacetophenone 1 on condensation with aroyl/heteroyl chlorides in pyridine gives esters, 2-acyl-4-acetamidophenyl aroylates / heteroylates 2 which are subjected to B.V. transformation to get 1-aryl-3-[2′-hydroxy-5′-acetamidophenyl]-1,3-propanediones 3. The 1,3-propanediones 3 when condensed with 2-aminobenzenethiols in dimethyl sulfoxide yield the title compounds, 2-[2′-hydroxy-5′-acetamidobenzoyl]-3-aryl/heteryl7- substituted-4H-1,4-benzothiazines 4. The microbial activity of the title compounds has been evaluated.
- Patil,Bondge,Bhingolikar,Mane
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p. 1513 - 1515
(2007/10/03)
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