A short synthesis of argatroban: A potent selective thrombin inhibitor
Argatroban was synthesized in seven steps from 4-methylpiperidine. The condensation of (±)-trans-benzyl 4-methylpipecolic acid ester with Nα-Boc-Nω-nitro-L-arginine led to two diastereomers that were separated. One of them is the precursor of argatroban.
Cossy, Janine,Belotti, Damien
p. 1989 - 1992
(2007/10/03)
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