The benzene ring in indoles has been aminomethylated in high yield by reaction with methylolphtalimide followed by hydrazinolysis of the phtalimidomethyl derivatives.In the hydrazinolysis of one of the phtalimidomethyl compounds, an intermediate product (the amino-methylindole phtalazine) was isolated and characterized.
Muminov, A.,Yudin, L. G.,Zinchenko, E. Ya.,Romanova, N. N.,Kost, A. N.
NEW POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR
The present invention relates to indole derivatives useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said com- pounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.
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Page/Page column 30
(2014/04/17)
Positive allosteric modulators of nicotinic acetylcholine receptor
The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.
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(2012/10/08)
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