COMPOSITION FOR DIAGNOSIS OF AMYLOID-RELATED DISEASE
There is provided a composition comprising a compound represented by general formula (I), wherein Rl represents a 5-iodothiophen-2-yl group or the like, and R2 represents a 4-dimethylaminophenyl group or the like. This composition is useful for diagnosis of an amyloid-related disease such as Alzheimer's disease because the compound has high binding specificity to amyloid β protein, high permeability through the blood-brain barrier, and a property of being rapidly eliminated from sites other than senile plaques in the brain.
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(2010/12/29)
COMPOSITION FOR DIAGNOSING AMYLOID-RELATED DISEASE
There is provided a composition comprising a compound represented by general formula (I), wherein R1 represents a 5-iodothiophen-2-yl group or the like, and R2 represents a 4-dimethylaminophenyl group or the like. This composition is useful for diagnosis of an amyloid-related disease such as Alzheimer's disease because the compound has high binding specificity to amyloid β protein, high permeability through the blood-brain barrier, and a property of being rapidly eliminated from sites other than senile plaques in the brain.
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Page/Page column 26; 50
(2009/04/23)
Convenient amination of weakly activated thiophenes, furans and selenophenes in aqueous media
We describe herein a new amination procedure of weakly activated heterocyclic bromo derivatives in aqueous media. The base catalysed mechanism of this reaction is also confirmed. Moreover, the application of this strategy to the preparation of amino furans and selenophenes is outlined.
Prim, Damien,Kirsch, Gilbert
p. 6511 - 6526
(2007/10/03)
5-SUBSTITUTED 2-FURANCARBALDEHYDES AND WATER-SOLUBLE FURAN DERIVATIVES
5-Halo-2-furaldehydes Ia, Ib react with trimethylamine in aprotic solvents to furnish 5-trimethylamonium salts of 2-furaldehyde IIa, IIb.The reactivity of this salt was utilized for a simple preparation of 5-substituted 2-furaldehydes IV in water at room temperature.The possibility to synthesize azomethines V and ethylenes VI, having the trimethylammonium group in position 5 of the furan ring maintained, is discussed.
Vegh, Daniel,Kovac, Jaroslav,Dandarova, Miroslava
p. 961 - 966
(2007/10/02)
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