3-Arylamino-quinoxaline-2-carboxamides inhibit the PI3K/Akt/mTOR signaling pathways to activate P53 and induce apoptosis
Thirty-eight new 3-arylaminoquinoxaline-2-carboxamide derivatives were in silico designed, synthesized and their cytotoxicity against five human cancer cell lines and one normal cells WI-38 were evaluated. Molecular mechanism studies indicated that N-(3-A
A facile synthesis of 3-hydroxy-N-(4-oxo-2-arylthiazolidin-3-yl)quinoxaline-2-carboxamides and N-(3-chloro-2-oxo-4-arylazetidin-1-yl)-3-hydroxyquinoxaline-2-carboxamides
o-Phenylenediamine reacts with diethylbromo malonate to form ethyl-1,2,3,4-tetrahydro-3-oxoquinoxaline-2-carboxylate 2, which reacts with hydrazinehydrate to form 3-hydroxyquinoxaline-2-carbohydrazide 3. Compound 3 on condensation with different aromatic aldehydes gives N'-arylidene-3-hydroxyquinoxaline-2-carbohydrazides 4 which is cyclised with chloroacetyl chloride and thioglycolic acid to obtain N-(3-chloro-2-oxo-4-arylazetidin-1-yl)-3-hydroxyquinoxaline-2-carboxamides 5 and 3-hydroxy-N-(4-oxo-2-phenylthiazolidin-3-yl)quinoxaline-2-carboxamides 6 respectively. The structures of these compounds are confirmed by 1H NMR and LC-MS data.
Haripriya,Laxminarayana,Thirumala Chary
p. 1222 - 1225
(2014/12/10)
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