Short synthesis of 4-chloro-4′-(chlorodifluoromethoxy)benzophenone
A one-pot, highly selective synthesis of 4-chloro-4′-(chlorodifluoromethoxy)benzophenone suitable for an industrial scale-up was developed. Fluorination of 4-(trichloromethoxy)benzoyl chloride at -20°C with HF to 4-(chlorodifluoromethoxy)benzoyl fluoride followed by an in situ Friedel-Crafts reaction with chlorobenzene in the presence of BF3 at -5°C yielded the title compound in excellent yield.
Karrer, Friedrich,Meier, Hans,Pascual, Alfons
p. 81 - 84
(2007/10/03)
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