- Novel pregnanoic acid derivatives
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Steroids of the formula SPC1 Wherein X is a hydrogen atom, a halogen atom or methyl; Y is a hydrogen atom or a halogen atom; Z is carbonyl, β-acyloxymethylene or, when Y is a hydrogen atom, also methylene; R1 is a hydrogen atom or methyl; R2 is a hydrogen atom, an alkali metal atom or optionally substituted hydrocarbon; and --A--B-- is --CH=CH--, --CCl=CH-- or when at least one of X, Y and R1 is other than a hydrogen atom, --CH2 --CH2 --, which can be produced by oxidizing a corresponding 20-hydroxy steroid or a corresponding 21-aldehyde, possess topical anti-inflammatory activity.
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