Biosynthesis of a thiamin antivitamin in clostridium botulinum
Bacimethrin-derived 2′-methoxythiamin pyrophosphate inhibits microbial growth by disrupting metabolic pathways dependent on thiamin-utilizing enzymes. This study describes the discovery of the bacimethrin biosynthetic gene cluster of Clostridium botulinum A ATCC 19397 and in vitro reconstitution of bacimethrin biosynthesis from cytidine 5′-monophosphate.
Cooper, Lisa E.,O'Leary, Seán E.,Begley, Tadhg P.
p. 2215 - 2217
(2014/05/06)
Synthesis of Pyrido[2,3-d]pyrimidines from Aminopyrimidinecarbaldehydes
2-Metboxy-4-amino-5-pyrimidinecarbaldebyde (2a) as well as its 6-methyl 2b and 6-phenyl derivatives 2c were prepared by reduction of the corresponding aminopyrimidinecarbonitriles 1. Catalytic hydrogenation of 1a, 1b gives 5-hydroxymethylpyrimidines 3a, 3
Perandones, Francisco,Soto, Jose L.
p. 413 - 419
(2007/10/03)
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