- Trifluoroacetylation of methylpyridines and other methylazines: A convenient access to trifluoroacetonylazines
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Treatment of methyl substituted azines, such as pyridine, pyrimidine, quinoline, oxazole, benzoxazole, benzimidazole, and benzothiazole, with trifluoroacetic anhydride in the presence of pyridine at room temperature gave the corresponding trifluoroacetonyl substituted azines in good yields.
- Kawase, Masami,Teshima, Mutsumi,Saito, Setsuo,Tani, Satoru
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- Chemoenzymatic Asymmetric Synthesis of Pyridine-Based α-Fluorinated Secondary Alcohols
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Fluoro-substituted and heteroaromatic compounds are valuable intermediates for a variety of applications in pharma- and agrochemistry and synthetic chemistry. This study investigates the chemoenzymatic preparation of chiral alcohols bearing a heteroaromatic ring with an increasing degree of fluorination in α-position. Starting from readily available picoline derivatives prochiral α-halogenated acyl moieties were introduced with excellent selectivity and 64–95 % yield. The formed carbonyl group was subsequently reduced to the corresponding alcohols using the alcohol dehydrogenase from Lactobacillus kefir, yielding an enantiomeric excess of 95–>99 % and up to 98 % yield.
- Broese, Timo,Ehlers, Peter,Langer, Peter,von Langermann, Jan
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p. 3314 - 3318
(2021/10/12)
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- Reductive transformation of V(iii) precursors into vanadium(ii) oxide nanowires
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Vanadium(ii) oxide nanostructures are promising materials for supercapacitors and electrocatalysis because of their excellent electrochemical properties and high surface area. In this study, new homoleptic vanadium(iii) complexes with bi-dentate O,N-chelating heteroarylalkenol ligands (DmoxCHCOCF3, PyCHCOCF3 and PyNCOCF3) were synthesized and successfully transformed by reductive conversion into VO nanowires. The chemical identity of V(iii) complexes and their redox behaviour were unambiguously established by single crystal X-ray diffraction studies, cyclic voltammetry, spectrometric studies and DFT calculations. Transformation into the metastable VO phase was verified by powder X-ray diffraction and thermo-gravimetry. Transmission electron microscopy and X-ray photoelectron spectroscopy data confirmed the morphology and chemical composition of VO nanostructures, respectively.
- Ojelere, Olusola,Graf, David,Ludwig, Tim,Vogt, Nicholas,Klein, Axel,Mathur, Sanjay
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p. 6842 - 6849
(2018/06/01)
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