- Preparation method of azlocillin and preparation method of azlocillin sodium freeze-dried powder for injection
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The invention discloses a preparation method of azlocillin and a preparation method of azlocillin sodium freeze-dried powder for injection. The preparation method of the azlocillin comprises the steps that 25-35 parts of an ampicillin thihydrate, 55-65 parts of acetone, 240-260 parts of water and 4-6 parts of dioxane and tetrahydrofuran are added into a reaction container by weight under the room temperature condition and stirred to be uniform, wherein the weight part ratio of dioxane to tetrahydrofuran is (6-8):1; 6-12 parts by weight of triethylamine is dropwise added into the reaction container when the temperature of the materials in the reaction container is lowered to 10 DEG C-15 DEG C, and stirring is performed to enable the solution in the reaction container to be completely clear; 9.10-12.74 parts by weight of 1-chloroformyl-2-imidazolidinone is slowly added into the reaction container when the temperature of the materials is lowered to 5 DEG C-10 DEG C, the temperature is kept at 15 DEG C-20 DEG C, and reacting under stirring is performed for 2.5-3.5 h; the pH is regulated to be 3-4 by adding hydrochloric acid, crystallization of the azlocillin is performed under the 3 DEG C-5 DEG C condition, and a precipitate is separated out; filtering is performed, and a precipitate is taken, leached by acetone and then subjected to vacuum drying. The preparation method of the azocillin is high in yield, the prepared azocillin is high in purity, and no solvent is retained.
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Paragraph 0038; 0039; 0040; 0041; 0042; 0043
(2016/11/21)
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- A Azlocillin sodium freeze-dried powder preparation method (by machine translation)
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The invention discloses a Azlocillin sodium method for preparing freeze-dried powder injection, also discloses a method for preparing arab League Luo river Xilin acid, the invention provides a method for preparing arab League Luo river Xilin acid high yield, Azlocillin acid with high purity obtained, and there is no residual solvent. (by machine translation)
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Paragraph 0031; 0045; 0046; 0047; 0048; 0049; 0050
(2016/12/12)
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