NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS
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(2008/06/13)
Synthesis and antineoplastic evaluations of 5,8-bis[(aminoalkyl)amino]-1-azaanthracene-9,10-diones
Several 5,8-bis[(aminoalkyl)amino]-1-azaanthracene-9,10-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Comparisons are made to the corresponding carbocyclic analogues. One of the aza analogues showed modest in vivo activity.
Krapcho,Landi Jr.,Hacker,McCormack
p. 1124 - 1126
(2007/10/02)
Synthesis of Azaanthraquinones: Homolytic Substitution of Pyridines
Synthesis of specific di- and tri-hydroxyazaanthraquinones by Friedel-Crafts procedures is limited by orientational ambiguity and by the lack of reactivity of pyridine derivatives in electrophilic acylation processes; however, suitable pyridines have been made to undergo radical benzoylation and benzylation at unsubstituted positions 2, 4 and 6.In particular, derivatives of pyridine-3-carbonitrile have been benzoylated at positions 2 and 4.Ring closure by intramolecular Houben-Hoesch reaction has then led to specifically substituted 1- and 2-azaanthraquinones and thence to the antibiotic bostrycoidin (1).
Cameron, Donald W.,Deutscher, Kenneth R.,Feutrill, Geoffrey I.,Hunt, Dianne E.
p. 1451 - 1468
(2007/10/02)
Preparation of certain biologically acitve anthraquinone derivatives containing nitrogen.
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CORE,KIRCH
p. 478 - 481
(2007/10/05)
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