Lipophilic indole mediated chemoselective α-monobromination of 1,3-dicarbonyl compounds
A mild and efficient mono-selective bromination of 1,3-dicarbonyl compounds has been developed using lipophilic indole catalysts. Inexpensive and commercially available N-bromosuccinimide (NBS) was used as the brominating reagent. The selectivity was further enhanced when using stoichiometric amount of 3-bromoindole species. Mechanistic studies reveal that the indole catalyst has dual functions in the mono-bromination process.
Wong, Jonathan,Ke, Zhihai,Yeung, Ying-Yeung
(2020/03/04)
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