- Preparation method of meto-Iodobenzylguanidine
-
The invention relates to a preparation method of I-MIBG (meto-Iodobenzylguanidine). The method comprises the following steps: heating meto-Iodobenzylguanidine sulfate, stannous mono-sulphate, a reducing agent, copper sulfate and NaI in a boiling water bath, standing after finishing the reaction, taking a supernatant liquid, and filtering the supernatant liquid with a microfiltration membrane. Sodium thiosulfate and/or sodium thiosulfate are/is taken as the reducing agent to prepare the meto-Iodobenzylguanidine sulfate, the prepared I-MIBG is high in radiochemical purity and good in stability, and the radiochemical purity of the prepared I-MIBG is still at a relatively high level after 48 hours.
- -
-
Paragraph 0028; 0029
(2017/02/17)
-
- Substituent effects. 14. Anomalous dissociation constants in water-organic solvent mixtures: benzylammonium ions and related systems
-
Thermodynamic dissociation constants in various water-organic solvent mixtures are given for benzylammonium, benzyldialkylammonium, and (2-phenylethyl)ammonium ions.Deviations from the Hammett equation (Eqn. 1) are similar to those observed for carboxylic acids, but of opposite sign.The extended Hammett equation (Eqn. 3), containing the hydrophobic constant, ?, yields good correlations.Derived secondary normal sigma values are exemplified.
- Hoefnagel, A. J.,Vos, R. H. de,Wepster, B. M.
-
-