Palladium-catalyzed sulfination of aryl and heteroaryl halides: Direct access to sulfones and sulfonamides
A novel palladium-catalyzed sulfination of aryl and heteroaryl halides is described. This reaction operates under mild conditions and provides access to a wide range of aryl and heteroaryl sulfinates, a useful and versatile class of synthetic intermediates. Capitalizing on this sulfination reaction, one-pot protocols allowing direct access to sulfones and sulfonamides have also been developed. The practicality of these transformations is illustrated with the parallel synthesis of analogues of the drug Viagra.
Shavnya, Andrei,Coffey, Steven B.,Smith, Aaron C.,Mascitti, Vincent
supporting information
p. 6226 - 6229
(2014/01/17)
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