- Green synthesis of novel bis(hexahydro-1H-xanthene-1,8(2H)-diones) employing p-toluenesulfonic acid (p-TSA) as a solid acid catalyst
-
Green synthesis of novel bis(hexahydro-1H-xanthene-1,8(2H)-diones) which are linked to aliphatic or aromatic spacers via ether or ester linkages were performed in good to excellent yields by the reaction of 5,5-dimethyl-1,3-cyclohexanedione with the appropriate bis-aldehydes using p-TSA as an organic acid solid catalyst. The reaction of the bis-aldehydes with barbituric acid or 1,3-dimethylbarbituric acid instead of 5,5-dimethyl-1,3-cyclohexanedione afforded the corresponding Knoevenagel condensation adducts in good yield.
- Darweesh, Ahmed F.,Salama, Soad K.,Abdelhamid, Ismail A.,Elwahy, Ahmed H. M.
-
p. 471 - 484
(2020/10/30)
-
- BIVALENT LECA INHIBITORS TARGETING BIOFILM FORMATION OF PSEUDOMONAS AERUGINOSA
-
The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa. The invention further relates to pharmaceutical compositions comprising these compounds and to therapeutic methods and uses of these compounds, in particular to therapeutic methods and uses for the treatment of Pseudomonas aeruginosa infections in a subject. The invention also relates to imaging of infections, such as biofilms produced by Pseudomonas aeruginosa, by using these divalent compounds.
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Page/Page column 31-32; 42
(2021/05/15)
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- A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate
-
Chronic infections with Pseudomonas aeruginosa are associated with the formation of bacterial biofilms. The tetrameric P. aeruginosa lectin LecA is a virulence factor and an anti-biofilm drug target. Increasing the overall binding affinity by multivalent
- Hirsch, Anna K. H.,Imberty, Anne,Kinsinger, Thorsten,Kuhaudomlarp, Sakonwan,Lepsik, Martin,Minervini, Saverio,Titz, Alexander,Yousaf, Sultaan,Zahorska, Eva
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p. 8822 - 8825
(2020/08/17)
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- Lewis acid catalyzed reactivity switch: Pseudo three-component annulation of nitrosoarenes and (epoxy)styrenes
-
A Lewis acid catalyzed annulation reaction via arene functionalization of nitrosoarenes and C-C cleavage of (epoxy)styrene to provide arylquinolines is reported. The Lewis acid catalyst altered the annulation pattern providing arylquinolines instead of oxazolidines. The reaction with styrene resulted in a mixture of 2,4-diarylquinoline and 4-Arylquinoline, while only 3-Arylquinoline was formed from the reaction of epoxystyrene. This journal is
- Purkait, Anisha,Saha, Subhajit,Ghosh, Santanu,Jana, Chandan K.
-
supporting information
p. 15032 - 15035
(2020/12/22)
-
- Novel 2-cyanoacrylamido-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives as potent anticancer agents
-
Ethyl 2-acrylamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate as well as its corresponding bis-derivatives, 5–10, with aliphatic linkers were synthesized, fully characterized, and tested as novel anticancer agents. The targeted compounds, 5–10, wer
- Sroor, Farid M.,Aboelenin, Mohamad M.,Mahrous, Karima F.,Mahmoud, Khaled,Elwahy, Ahmed H. M.,Abdelhamid, Ismail A.
-
-
- Polyethylene glycol-bonded triethylammonium l-prolinate: A new biodegradable amino-acid-based ionic liquid for the one-pot synthesis of bis(pyrazolyl)methanes as DNA binding agents
-
Polyethylene glycol-bonded triethylammonium l-prolinate ([PEG-TEA]LP) was prepared as a new, highly efficient, reusable and biodegradable amino-acid-based ionic liquid catalyst using cheap and easily accessible starting materials. The [PEG-TEA]LP chemical
- Kordnezhadian, Reza,Shekouhy, Mohsen,Karimian, Somaye,Tavaf, Zohreh,Malek-Hosseini, Saeed,Shahsavani, Mohammad Bagher,Amirghofran, Zahra,Yousefi, Reza,Khalafi-Nezhad, Ali
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p. 16995 - 17012
(2020/11/02)
-
- Prospective new amidinothiazoles as leukotriene B4 inhibitors
-
An efficient and one-step synthesis of the versatile, hitherto new derivatives resembling LY293111, a prospective potent antagonist of the leukotriene B4 (LTB4) receptor, were reported. The strategy was based on the synthesis of an amidinothiazole ring, c
- Aly, Ashraf A.,Ibrahim, Mahmoud A.A.,El-Sheref, Essmat M.,Hassan, Alaa M.A.,Brown, Alan B.
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p. 414 - 427
(2018/09/18)
-
- Governing the DNA-binding mode of styryl dyes by the length of their alkyl substituents-from intercalation to major groove binding
-
A series of monomeric and homodimeric 4-alkoxystyryl(pyridinium) dyes was synthesized and their DNA-binding properties were investigated. We found that the length of the alkyl substituent has a crucial influence on the binding mode of the dyes, although t
- Berdnikova, Daria V.,Sosnin, Nikolai I.,Fedorova, Olga A.,Ihmels, Heiko
-
p. 545 - 554
(2018/02/07)
-
- Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance
-
The S108N mutation of dihydrofolate reductase (DHFR) renders Plasmodium falciparum malaria parasites resistant to pyrimethamine through steric clash with the rigid side chain of the inhibitor. Inhibitors with flexible side chains can avoid this clash and
- Tarnchompoo, Bongkoch,Chitnumsub, Penchit,Jaruwat, Aritsara,Shaw, Philip J.,Vanichtanankul, Jarunee,Poen, Sinothai,Rattanajak, Roonglawan,Wongsombat, Chayaphat,Tonsomboon, Aunchalee,Decharuangsilp, Sasithorn,Anukunwithaya, Tosapol,Arwon, Uthai,Kamchonwongpaisan, Sumalee,Yuthavong, Yongyuth
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supporting information
p. 1235 - 1240
(2019/01/04)
-
- Biological activities and docking studies on novel bis 1,4-DHPS linked to arene core via ether or ester linkage
-
Background: Novel bis(1,4-dihydropyridine) derivatives linked to arene core via ester 5-7 as well as ether linkages 10-12 were prepared, and their structures were confirmed by several spectral tools. They were evaluated as anticancer agents on A549 and MC
- Ibrahim, Nada S.,Mohamed, Magda F.,Elwahy, Ahmed H. M.,Abdelhamid, Ismail A.
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p. 1036 - 1045
(2018/09/29)
-
- An efficient multigram-scale synthesis of 4-(ω-chloroalkoxy)phenols
-
Efficient multigram two-step syntheses of 4-(2-chloroethoxy)phenol and 4-(3-chloropropoxy)phenol in >70% yields starting from 4-hydroxybenzaldehyde and reagents with general formula Cl(CH2)nX (X = Cl, n = 2; X = OTs, n = 3) are proposed. 4-(2-Chloroethoxy)phenol can also be conveniently prepared from 4-methoxyphenol and 1,2-dichloroethane. The compounds thus obtained can be used in carbohydrate chemistry to synthesize glycosides bearing "universal" 4-(ω-chloroalkoxy)phenyl aglycons.
- Zinin,Stepanova,Jost,Kondakov,Shpirt,Chizhov,Torgov,Kononov
-
p. 304 - 312
(2017/07/11)
-
- Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors
-
Known PTP1B inhibitors with bis-anionic moieties exhibit potent inhibitory activity, good selectivity, however, they are incapable of penetrating cellular membranes. Based upon our finding of a new pharmacophoric group in inhibition of PTP1B and the struc
- Yang, Fengzhi,Xie, Fangzhou,Zhang, Ying,Xia, Yu,Liu, Wenlu,Jiang, Faqin,Lam, Celine,Qiao, Yixue,Xie, Dongsheng,Li, Jianqi,Fu, Lei
-
supporting information
p. 2166 - 2170
(2017/04/27)
-
- Novel PTP1B enzyme inhibitor, preparation method and applications thereof
-
The present invention provides a novel PTP1B enzyme inhibitor, a preparation method and applications thereof, and particularly discloses a class of bis 2-substituted ethylene sulfonate compounds and a preparation method thereof, and uses of the bis 2-substituted ethylene sulfonate compounds as the PTP1B enzyme activity inhibitor. According to the present invention, the prepared novel compound has good PTP1B enzyme activity inhibition effect, and has the application value in preparation of drugs for treatment and prevention of diabetes and obesity.
- -
-
Paragraph 0111-0113
(2017/08/31)
-
- Synthesis, Molecular Docking Studies, and Anticonvulsant Evaluation of Novel bis-Phenylhydrazones against Chemically induced Seizures in Mice
-
A series of novel bis-phenylhydrazones were synthesized by the condensation of dialdehydes with phenylhydrazine to evaluate them for their anticonvulsant activity. Efficacy of newly synthesized compounds against pentylenetetrazole (PTZ)-induced, strychnin
- Siddiqi, Humaira Masood,Tabasum, Aneela,Qasim, Sumera,Akhtar, Muhammad Shoaib,Kalsoom, Saima,Ansari, Farzana Latif
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p. 940 - 952
(2017/09/01)
-
- Synthesis, screening and in silico simulations of anti-parasitic propamidine/benzimidazole derivatives
-
Background: We designed hybrid molecules between propamidine and benzimidazole in order to retain the antiprotozoal action, but decreasing the toxic effect of the molecule. Objective: Design and prepare 12 hybrids for testing their antiparasitic effect ov
- Méndez-Cuesta, Carlos A.,Herrera-Rueda, Miguel ángel,Hidalgo-Figueroa, Sergio,Tlahuext, Hugo,Moo-Puc, Rosa,Chale-Dzul, Juan Bautista,Chan-Bacab, Manuel,Ortega-Morales, Benjamín Otto,Hernández-Nú?ez, Emanuel,Méndez-Lucio, Oscar,Medina-Franco, José L.,NavarreteVázquez, Gabriel
-
-
- Synthesis and multistate characterization of bis-flavylium dications-symmetric resorcinol- and phloroglucinol-type derivatives as stochastic systems
-
Two symmetric bis-flavylium dications were readily synthesized and further evaluated for their multistate profile. Both systems were shown to be fully stochastic and behave like a single compound suggesting that the two flavylium moieties do not communica
- Basílio,Garnier,Avó,Danel,Chassaing,Pina
-
p. 69698 - 69707
(2016/08/06)
-
- Novel Bis(2-(5-((5-phenyl-1H-tetrazol-1-yl)methyl)-4H-1,2,4-triazol-3-yl)phenoxy)Alkanes: Synthesis and Characterization
-
In this study, 10 different substituted aromatic bis-benzaldehydes were synthesized by treating hydroxy benzaldehydes with various dihaloalkanes. Bis aldehydes 5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j were treated with 2-(5-phenyl-1H-tetrazole-1-yl)acetohyd
- Saeed, Aamer,Qasim, Muhammad,Hussain, Majid
-
p. 1114 - 1118
(2015/08/06)
-
- Synthesis, characterization and anticancer activity of dinuclear ruthenium(II) complexes linked by an alkyl chain
-
A series of 1,10-phenanthroline-based dinucleating bridging ligands BL1-3 and their dinuclear ruthenium Ru(ii) complexes [(bpy)2Ru(BL1-3)Ru(bpy)2](PF6)4 (bpy = 2,2′-bipyridine; PF6/su
- Zhang, Yan,Lai, Lu,Cai, Ping,Cheng, Gong-Zhen,Xu, Xi-Ming,Liu, Yi
-
p. 5805 - 5812
(2015/07/07)
-
- Synthesis and mesomorphic properties of new methylene-linked linear symmetrical liquid crystal dimers
-
A series of methylene-linked symmetrical liquid crystal dimers were synthesized. Their structures were confirmed by physicochemical techniques. Differential scanning calorimetry and polarizing optical microscopy verified the liquid crystal behaviors and t
- Al-Hamdani, Uhood J.,Al-Ibrahim, Aiman G.,Abbo, Hanna S.,Titinchi, Salam J.J.
-
-
- One-pot synthesis of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols and evaluation of their antimicrobial activity
-
Abstract A new series of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols were synthesized by reaction of bis(formylphenyl)glycols with benzil/benzoin and ammonium acetate in presence of iodine/acetic acid in ethanol. All newly synthesized compounds were char
- Linga Goud,Ramesh,Ashok,Prabhakar Reddy
-
p. 673 - 678
(2015/05/05)
-
- New bispyrazoline derivatives built around aliphatic chains: Synthesis, characterization and antimicrobial studies
-
The bispyrazolines 3a-3h built around the alkyl chains of varying lengths have been synthesized from the cyclization reactions of bischalcones with phenyl hydrazine. The bischalcones 2a-2h were obtained from the Claisen-Schmidt reactions of acetophenone w
- Yusuf, Mohamad,Jain, Payal
-
p. 117 - 127
(2013/05/08)
-
- Biological evaluation of bisbenzaldehydes against four Mycobacterium species
-
A series of bisbenzaldehydes and structurally related analogs, conveniently synthesized via microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two Mycobacterium avium subspecies. Among the 33 substances that were tested, compound 12, i.e. 4,4′-[1,12-dodecanediyl(oxy)]bisbenzaldehyde, emerged as the most promising hit. Its activity was further confirmed in an intracellular growth inhibition assay of M. tb in murine J774 A.1 macrophages. None of the compounds showed significant cytotoxicity on human C3A hepatocytes in a neutral red dye uptake assay and no genotoxicity or mutagenicity was observed as demonstrated by a VITOTOX test and confirmed with a comet assay.
- Cappoen, Davie,Forge, Delphine,Vercammen, Frank,Mathys, Vanessa,Kiass, Mehdi,Roupie, Virginie,Anthonissen, Roel,Verschaeve, Luc,Vanden Eynde, Jean Jacques,Huygen, Kris
-
p. 731 - 738
(2013/07/25)
-
- Four-step route to novel bisflavylium dications - First synthesis of phloroglucinol-type derivatives
-
Various bisflavylium dications have been prepared in an efficient four-step manner utilizing the acid-mediated condensation between bis(arylethynylketones) and activated phenols as the key step. Of special note is that phloroglucinol-type bisflavylium sal
- Kueny-Stotz, Marie,Brouillard, Raymond,Chassaing, Stefan
-
supporting information
p. 2053 - 2058,6
(2020/07/31)
-
- Chelate cooperativity and spacer length effects on the assembly thermodynamics and kinetics of divalent pseudorotaxanes
-
Homo- and heterodivalent crown-ammonium pseudorotaxanes with different spacers connecting the two axle ammonium binding sites have been synthesized and characterized by NMR spectroscopy and ESI mass spectrometry. The homodivalent pseudorotaxanes are investigated with respect to the thermodynamics of divalent binding and to chelate cooperativity. The shortest spacer exhibits a chelate cooperativity much stronger than that of the longer spacers. On the basis of crystal structure, this can be explained by a noninnocent spacer, which contributes to the binding strength in addition to the two binding sites. Already very subtle changes in the spacer length, i.e., the introduction of an additional methylene group, cause substantial changes in the magnitude of cooperative binding as expressed in the large differences in effective molarity. With a similar series of heterodivalent pseudorotaxanes, the spacer effects on the barrier for the intramolecular threading step has been examined with the result that the shortest spacer causes a strained transition structure and thus the second binding event occurs slower than that of the longer spacers. The activation enthalpies and entropies show clear trends. While the longer spacers reduce the enthalpic strain that is present in the transition state for the shortest member of the series, the longer spacers become entropically slightly more unfavorable because of conformational fixation of the spacer chain during the second binding event. These results clearly show the noninnocent spacers to complicate the analysis of multivalent binding. An approximate description which considers the binding sites to be connected just by a flexible chain turns out to be more a rough approximation than a good model. The second conclusion from the results presented here is that multivalency is expressed in both the thermodynamics and the kinetics in different ways. A spacer optimized for strong binding is suboptimal for fast pseudorotaxane formation.
- Jiang, Wei,Nowosinski, Karol,Loew, Nora L.,Dzyuba, Egor V.,Klautzsch, Fabian,Schaefer, Andreas,Huuskonen, Juhani,Rissanen, Kari,Schalley, Christoph A.
-
supporting information; experimental part
p. 1860 - 1868
(2012/03/11)
-
- Bis(oxyphenylene)benzimidazoles: A novel class of anti-Plasmodium falciparum agents
-
A small library of 26 2,2′-[alkane-α,ω- diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium
- Mayence, Annie,Vanden Eynde, Jean Jacques,Kaiser, Marcel,Brun, Reto,Yarlett, Nigel,Huang, Tien L.
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experimental part
p. 7493 - 7500
(2012/01/03)
-
- Novel bisbenzimidazoles with antileishmanial effectiveness
-
A small library of 2,2′-[(α,ω-alkanediylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and screened in vitro against Pneumocystis carinii, Trypanosoma brucei rhodesiense, and Leishmania donovani. Among the six tested compounds two derivatives e
- Mayence, Annie,Pietka, Aurelie,Collins, Margaret S.,Cushion, Melanie T.,Tekwani, Babu L.,Huang, Tien L.,Vanden Eynde, Jean Jacques
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p. 2658 - 2661
(2008/12/21)
-
- Synthesis of symmetric liquid crystal dimers based on azo and imine groups and investigation of phase behaviour by varying alkoxy terminal chain length
-
With the objective to study the effect of alkoxy terminal chain length on mesomorphic properties of liquid crystals, we have synthesized two (Azo and Imine) different series of dimesogens by varying terminal alkoxy chain length (n = 6-12) with a short spacer unit in between two mesogens. Transition temperatures and phase characterization were studied by DSC, POM and XRD analysis. It was found that all the dimers show mesomorphic properties and the change in terminal alkoxy chain length has pronounced effect on the smectic phase window. In the DSC cooling scan, the smectic phase window of azo compounds increased from 6.4°C (2A6) to 16.0°C(2A12), whereas in Schiff base compounds, it increased from 9.2°C (2S6) to 31.0°C(2S12). Further, the 2A11 dimer was found to undergo photo induced configurational changes.
- Kim, Tae Hyeong,Lee, Chang Sin,Ramaraj,Jeon, Hye Jin,Song, Hyun Hoon,Lee, Soo Min,Yoon, Kuk Ro
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experimental part
p. 102 - 116
(2010/03/04)
-
- PROCESS FOR THE PREPARATION OF PORPHYRIN DERIVATIVES AS ANTIMICROBIAL AGENTS BY PHOTODYNAMIC THERAPY (PDT)
-
There is provided a process for the preparation of 5,15-bis-[4-(3- trrmethylarnmonio-propyloxy)-phenyl]-porphyrin dihalide, wherein the process comprises step (a) of providing 4-(3-bromopropyloxy)benzaldehyde, step (b) of providing dipyrrolmethane, step (c) of reacting the 4-(3-bromopropyloxy)- benzaldehyde with the dipyrrol-methane, together with trifluoro acetic acid, in the presence of an oxidation reagent to produce 5,15-bis-[4-(3-bromo- propyloxy)-phenyl] -porphyrin which is purified by Soxhlet extraction from the adsorbed state on a bed of alumina under highly controlled conditions; and step (d) of reacting the 5,15-bis-[4-(3-bromo-propyloxy)-phenyl]-porphyrin with trimethylamine in the presence of dry dimethylformamide to produce 5,15-bis- [4-(3-trrmethylarnmonio-propyl-oxy)-phenyl] -porphyrin dibromide. In a preferred embodiment, the process further comprises step (e) of passing the 5, 15-bis-[4-(3 -1rimemylammonio-propyloxy)-phenyl]-porphyrin di-bromide produced in step (d) through an anion exchanger to produce 5,15-bis-[4-(3- trimethylammonio-propyloxy)-phenyl]-porphyrin dichloride. There is provided a process for the preparation of 5,15-bis-(4-{3-[(3-dimemylamino-propyl)- dimethyl-ammonio]-propyloxy} -phenyl] -porphyrin dihalide.
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-
Page/Page column title page; 18-20; Sheet 1/2
(2008/06/13)
-
- Synthesis and characterization of new organic phosphonates monomers as flame retardant additives for polymers
-
Commercially available polyphenols react with diethylphosphite to give polyphosphonates, which are easily transformed by LDA in good yields to polyorthohydroxy aryl phosphonates. Moreover, some bis-benzyl aminobenzyl phosphonates have been prepared in good yields. These new monomers are of great relevance for the synthesis of thermal resistant polycondensates containing phosphonate moieties.
- Finocchiaro, Paolo,Consiglio, Giuseppe A.,Imbrogiano, Andrea,Failla, Salvatore
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p. 1689 - 1701
(2008/02/11)
-
- DNA sequence-specific ligands: XII. Synthesis and cytological studies of dimeric hoechst 33258 molecules
-
We synthesized dimeric Hoechst dye molecules composed of two moieties of Hoechst 33258 fluorescent dye with the phenolic hydroxy groups tethered via pentamethylene, heptamethylene, or triethylene oxide linkers. A characteristic pattern of differential staining of chromosome preparations from human HL60 premonocytic leukemia cells was observed for all the three fluorescent dyes. The most contrasting pattern was obtained for the bisHoechst analogue with the heptamethylene linker; its quality was comparable with the picture obtained in the case of chromosome staining with 4′,6-diamidino-2-phenylindole. The ability to penetrate into live human fibroblasts was studied for the three bisHoechst compounds. The fluorescence intensity of nuclei of live and fixed cells stained with the penta- and heptamethylene-linked bisHoechst analogues was found to differ only slightly, whereas the fluorescence of the nuclei of live cells stained with triethylene oxide-linked bisHoechst was considerably weaker than that of the fixed cells. The bisHoechst molecules are new promising fluorescent dyes that can both differentially stain chromosome preparations and penetrate through cell and nuclear membranes and effectively stain cell nuclei.
- Gromyko,Popov,Mosoleva,Streltsov,Grokhovsky,Oleinikov,Zhuze
-
p. 344 - 351
(2008/02/03)
-
- Synthesis, anti-Trypanosoma cruzi activity and micelle interaction studies of bisguanylhydrazones analogous to pentamidine
-
Three new bisguanylhydrazones analogous to pentamidine were synthesized, fully characterized and tested as anti-Trypanosoma cruzi candidates. Contrary to literature reports, that bicationic compounds are more active than monocationic compounds against Try
- Borges, Márcia Narcizo,Messeder, Jorge Cardoso,Figueroa-Villar, José Daniel
-
p. 925 - 929
(2007/10/03)
-
- Synthesis and thermal properties of twin dimers containing cyanostilbene derivatives as a mesogenic group
-
We synthesized twin dimers (TDs) with different linking groups between a mesogenic group and a flexible spacer, different spacer length, and different terminal alkyl chain length to clarify the effect of these groups on the mesomorphic properties of the T
- Mihara,Ito,Koide
-
-
- Synthesis and thermal properties of twin dimers containing cyanostilbene groups as a mesogenic group
-
Twin dimers (TDs) with a different linking group (ester or ether) between the mesogenic group (cycmostilbene moiety) and the flexible spacer were synthesized to clarify the effect of the linking group on the mesomorphic properties. The sequence of the est
- Aoki,Mihara,Koide
-
-
- The syntheses of 4,4'-(1,n-dioxaalkane)-bisbenzaldehydes and 4,4'-(1,n- dioxaalkane)-bis(α-methoxy phenylacetic acids)
-
The syntheses of 4,4'-(1,n-dioxaalkane)-bis(α-methoxyphenylacetic acids) were conducted using a base-catalyzed reaction. The reactants were potassium hydroxide (or lithium hydroxide/lithium chloride), bromoform, methanol and 4,4'-(1,n-dioxaalkane)-bisbenz
- Jiang, Jianjun,Compere Jr., Edward L.
-
p. 1041 - 1050
(2007/10/03)
-
- Bisoxadiazolidine derivative
-
A bisoxadiazolidine dione derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as an insulin sensitivity-increasing drug, and a pharmaceutical composition thereof. STR1 each represents a phenylene group L: (1) an oxygen, (2) a STR2 (3) a --S(O)n --, (4) a --CO--, (5) a STR3 (6) an alkylene group or an alkenylene group which may respectively be interrupted with an oxygen atom and/or a sulfur atom.
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-
-
- THERMOTROPIC COMPOUNDS WITH TWO TERMINAL MESOGENIC UNITS AND A CENTRAL SPACER. 5. HOMOLOGOUS SERIES OF POLYMETHYLENE-α, ω-BIS(P-OXYBENZYLIDENE ANILINE)
-
Two series of new thermotropic compounds with two terminal mesogenic units, p-oxybenzylidene-p-substituted anilines, attached to both ends of central polymethylene spacer were prepared.The first series of compounds has central polymethylene spacers of var
- Jin, Jung-Il,Park, Joo-Hoon
-
p. 293 - 308
(2007/10/02)
-
- MESOGENIC POLYMERS. 6. TWO SERIES OF ISOMERIC POLYAZOMETHINES.
-
Two homologoous series of alternating rigid-flexible, main chain liquid crystalline polyimines are reported; one based on terephthaldehyde the other based on p-phenylenediamine. It was found through examination of optical microscopic, x-ray diffraction an
- Griffin,Britt,Hung,Steele
-
p. 305 - 314
(2007/10/02)
-