- The surprising diacylation of diethyl (ethoxycarbonylmethyl)phosphonate
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Deprotonation of diethyl (ethoxycarbonylmethyl)-phosphonate with NaH followed by treatment with acyl chlorides affords surprisingly the corresponding C,C-diacylated derivatives as the predominating products.
- Gulyás, Kinga V.,Keglevich, Gy?rgy
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p. 244 - 245
(2021/05/04)
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- Method for preparing 2-phosphonic acid ester base-1, 3-dicarbonyl derivative
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The invention discloses a method for preparing a 2-phosphonic acid ester base-1, 3-dicarbonyl derivative. A 1, 3-dicarbonyl derivative and trialkyl phosphite ester are used as starting materials, and a great variety of raw materials are easy to obtain. Varied types of products are obtained through the method, can be directly used, and can also be used for other further reactions. In addition, the reaction is performed in air, the condition is mild, the reaction time is short, the target product yield is high, pollution is small, the reaction operation and aftertreatment process is simple, and the method is suitable for industrial production.
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Paragraph 0041
(2016/10/10)
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- A simplified synthesis of the diastereomers of Levuglandin E2
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We report a synthesis of Levuglandin E2, as a mixture of easily separable diastereomers (15-E2-isoketals). The key feature is the protection of its reactive aldehyde as dimethyl acetal, which is introduced with 2,2-dimethoxyethanal and removed in minutes with Montmorillonite K-10. The synthesis could be modified to the preparation of 15-E2-isoketals with stable isotopes or with radiolabels. Copyright Taylor & Francis, Inc.
- Amarnath, Venkataraman,Amarnath, Kalyani,Masterson, Tina,Davies, Sean,Roberts II, Jackson
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p. 397 - 408
(2007/10/03)
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- On a safe and practical method for the preparation of β-keto phosphonates
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Acylations of the magnesium enolate derivatives of trimethyl and triethylphosphonoacetates, using a magnesium chloride-triethylamine system, lead to 2-acetylphosphonoacetates which are decarbalkoxylated to give β-keto phosphonates.
- Corbel, Bernard,L'Hostis-Kervella, Isabelle,Haelters, Jean-Pierre
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p. 2561 - 2568
(2007/10/03)
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