- Nitroimidazole compound as well as preparation method and application thereof
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The invention discloses a novel nitroimidazole compound as well as a preparation method and application thereof. The nitroimidazole compound has a general formula (I) shown in the specification.
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- SPIROCYCLIC COMPOUNDS
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Described herein are compounds of formula (I) (Formula (I)). The compounds of formula (I) act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
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Page/Page column 69
(2012/02/02)
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- Synthesis of oxaspiropiperidines as a strategy for lowering logD
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The syntheses of four new spiropiperidines designed as polar analogs of methyl 2-(3-azaspiro[5.5]undec-an-9-yl)acetate are described.
- Cernak, Timothy,Dykstra, Kevin,Levorse, Dorothy,Verras, Andreas,Balkovec, James,Nargund, Ravi,DeVita, Robert
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p. 6457 - 6459
(2011/12/22)
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- Cyclohexane derivatives and their use as therapeutic agents
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The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R17, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
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