Chemical degradation products of lignin and humic substances. Part II: Synthesis, structure verification and liquid) chromatographic separation of chlorinated protocatechualdehydes (3,4-dihydroxybenzaldehydes], 5-hydroxyvanillins (3,4-dihydroxy-5-methoxybenzaldehydes) and gallaldehydes (3,4,5-trihydroxybenzaldehydes)
All possible chloroprotocatechualdehydes, chlorogallaldehydes, 5-bromoprotocatechualdehyde and chloro-5-hydroxyvanillins (except 2-chloro-5-hydroxyvanillin) were synthesized. Their purity and structures were examined by liquid chromatography, mass spectrometry and other spectroscopic measurements. The details of the synthesis, liquid chromatographic separation and mass spectrometric features are discussed.
Hyotylainen
p. 1641 - 1656
(2007/10/03)
Comparative α- and β-adrenoceptor activity of 2- and 6-ring-chlorinated noradrenaline analogues
The α- and β-adrenoceptor activity of the 2- and 6-ring-chlorinated analogues of noradrenaline (norepinephrine) were evaluated in vitro. The 2-chloro-substituted analogue exhibits a far greater affinity for β1-chronotropic receptors than the 6-chloro-substituted analogue, whereas no significant differences are apparent for their α-adrenergic affinities.
Halogen substituted α-(aminoalkyl)-3,4-dihydroxybenzyl alcohols having β-adrenergic stimulant activity, particularly as selective bronchodilators. The α-aminomethyl derivatives are prepared by the condensation of an appropriately substituted styrene oxide with a primary amine followed by removal of the ether protective group(s). The α-aminoethyl or α-aminopropyl derivatives are prepared by the condensation of an appropriately substituted α-bromoalkyl phenyl ketone with an N-benzyl secondary amine followed by reduction of the ketone moiety and removal of the ether protective group(s).
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(2008/06/13)
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