- Tetrahydroxynaphthalene reductase: Catalytic properties of an enzyme involved in reductive asymmetric naphthol dearomatization
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In reduced circumstances: Tetrahydroxynaphthalene reductase shows a broad substrate range including alternate phenolic compounds and cyclic ketones. Structural modeling reveals major enzyme-substrate interactions; C-terminal truncation of the enzyme causes an altered substrate preference, in accordance with stabilization of the substrate by the C-terminal carboxylate (see picture). This effect allows the identification of a homologous enzyme. Copyright
- Schaetzle, Michael A.,Flemming, Stephan,Husain, Syed Masood,Richter, Michael,Guenther, Stefan,Mueller, Michael
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supporting information; body text
p. 2643 - 2646
(2012/05/04)
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- 6-SUBSTITUTED NICOTINAMIDE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS
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A compound of the formula (I) or a pharmaceutically acceptable salt, enantiomer, racemate, diastereomers or mixtures thereof, or a solvate thereof, formulations and methods of use thereof, as opioid receptor antagonists are disclosed wherein the variables are as described herein.
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- Ionic hydrogenation of dihydroxynaphthalenes with cyclohexane in the presence of aluminum bromide
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Reactions of 1,5-, 1,6-, 1,7-, 2,6-, and 2,7-dihydroxynaphthalenes with cyclohexane in the presence of excess aluminum bromide in methylene bromide quantitatively yield 5-, 6-, and 7-hydroxynaphthalen-1-ones and 6- and 7-hydroxynaphthalen-2-ones, respectively. Tricationic C-protonated complexes are presumed to be reactive intermediates in these processes.
- Ostashevskaya,Koltunov,Repinskaya
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p. 1474 - 1477
(2007/10/03)
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- Efficient synthesis of resin-bound α-TMSdiazoketones and their use in solid-phase organic synthesis
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α-TMSdiazoketones on a solid support could be simply and efficiently prepared by reaction of the corresponding resin-bound acid chlorides with excess TMSdiazomethane, without any bases. These α-TMSdiazoketones were used via carbenes or carbenoids for a variety of solid-phase reactions. These useful solid-phase reactions allow efficient construction of diverse compound libraries by use of combinatorial chemistry, due to the high reactivity and wide applications of the carbenes or carbenoids. (C) 2000 Elsevier Science Ltd.
- Iso, Yasuyoshi,Shindo, Hirohisa,Hamana, Hiroshi
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p. 5353 - 5361
(2007/10/03)
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- HYDROXYLATION DU BENZALDEHYDE ET DE CETONES AROMATIQUES PAR LE PEROXYDE D'HYDROGENE EN MILIEU SUPERACIDE
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Benzaldehyde and aromatic ketones are hydroxylated by hydrogen peroxide in SbF5-HF without formation of products arising from Baeyer-Villiger oxidation.
- Gesson, Jean-Pierre,Jacquesy, Jean-Claude,Jouannetaud, Marie-Paule,Morellet, Guy
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p. 3095 - 3098
(2007/10/02)
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