- Ultrasound-assisted and efficient knoevenagel condensation reaction catalyzed by silica sodium carbonate nanoparticles
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An efficient and ultrasound-assisted route to the synthesis of arylidene malononitriles/methylciano- or ethylciano acetates in a one-pot reaction catalyzed by silica sodium carbonate nanoparticles (SSC NPs) is described. In this reaction, SSC NPs demonstrated high efficiency as catalyst to obtain target products. By this achievement, a wide range of α,β-unsaturated compounds as Knoevenagel condensation products with good to excellent yields are obtained from reaction between numerous arylaldehydes, and malononitrile, methyl cianoacetate or ethyl cianoacetate. Target products which prepared in high yield and high purity can be candidate as important biologically active molecules. This method is an easy, cheap, rapid and highly efficient for the synthesis of desired products. In addition, capability of catalyst to separate from reaction mixture and reuse in further runs and being compatible with green chemistry are considered as other advantages of this procedure. All products were deduced from their FT-IR and FT-NMR spectroscopic and elemental analysis data.
- Pourshojaei, Yaghoub,Nikzad, Maryam,Eskandari, Khalil,Darijani, Mohammad-Hossein,Hassanzadeh, Abdolreza,Faghih-Mirzaei, Ehsan,Asadipour, Ali
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- With the plaque and A β of the nerve fiber entanglement having affinity to the compound and its preparation method
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The invention provides a compound provided with good affinity and tangled with an Abeta plaque and a nerve fiber. The structural general formula (I) of the compound is as shown in the specification, wherein W is a benzo-hexahydric aromatic ring or a hexah
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Paragraph 0143-0144
(2018/04/26)
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- An investigation on single crystal growth, structural, thermal and optical properties of a series of organic D-π-A push-pull materials
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We present the large single crystal growth of a series of donor-π-acceptor (D-π-A) push-pull chromophores; 4-N,N-dimethylamino-β-nitrostyrene (1), 2-(4-(dimethylamino)benzylidene)malononitrile (2), ethyl 2-cyano-3-(4-(dimethylamino)phenyl)acrylate (3) and
- Gupta, Vinod Kumar,Singh, Ram Adhar
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p. 38591 - 38600
(2015/07/28)
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- Microwave synthesis of α-cyano chalcones
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A novel methodology for facile production of α-cyano chalcones under microwave irradiation is described. Utilizing a Knoevenagel condensation between benzoylacetonitriles and aromatic aldehydes, substituted chalcones are generated via a 15-min, one-pot synthesis. Diversification of aromatic groups, including electron-withdrawing, electron-donating, and heterocyclic substitutions, has led to the isolation of over twenty colored, solid chalcone products. Furthermore the methodology can be extended to the synthesis of benzylidenemalononitriles as well as methyl and ethyl α-cyano cinnamates.
- Deshpande, Shyam J.,Leger, Paul R.,Sieck, Stephen R.
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supporting information; experimental part
p. 1772 - 1775
(2012/05/04)
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- Molecular rotors: synthesis and evaluation as viscosity sensors
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It has been shown that compounds containing the p-N,N-dialkylaminobenzylidene cyanoacetate motif can serve as fluorescent non-mechanical viscosity sensors. These compounds, referred to as molecular rotors, belong to a class of fluorescent probes that are
- Sutharsan, Jeyanthy,Lichlyter, Darcy,Wright, Nathan E.,Dakanali, Marianna,Haidekker, Mark A.,Theodorakis, Emmanuel A.
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experimental part
p. 2582 - 2588
(2010/05/01)
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- Tetra-n-butylammonium hydroxide (TBAH)-catalyzed Knoevenagel condensation: A facile synthesis of α-cyanoacrylates, α-cyanoacrylonitriles, and α-cyanoacrylamides
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Tetra-n-butylammonium hydroxide (TBAH) has been utilized as a novel and efficient catalyst for the Knoevenagel condensation of aldehydes with acidic methylene compounds such as methyl- and ethylcyanoacetate, malononitrile, and cyanoacetamide to afford sub
- Balalaie, Saeed,Bararjanian, Morteza
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p. 533 - 539
(2007/10/03)
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- Novel, efficient, and green procedure for the Knoevenagel condensation catalyzed by diammonium hydrogen phosphate in water
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Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds like methyl and ethyl cyanoacetate, malononitrile, and cyanoacetamide proceeds smoothly with stirring in water in the presence of 4 mol% of diammoniu
- Balalaie, Saeed,Bararjanian, Morteza,Hekmat, Shohreh,Salehi, Peyman
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p. 2549 - 2557
(2007/10/03)
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- Novel, efficient, and green procedure for the Knoevenagel condensation catalyzed by diammonium hydrogen phosphate in water
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Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds such as methyl and ethyl cyanoacetate, malononitrile, and cyanoacetamide proceeds smoothly with stirring in water in the presence of 4 mol% of diammo
- Balalaie, Saeed,Bararjanian, Morteza,Hekmat, Shohreh,Salehi, Peyman
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p. 3703 - 3711
(2007/10/03)
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- Hydrophilic molecular rotor derivatives - Synthesis and characterization
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Recent research shows high potential for some p-N,N- dialkylaminobenzylidenecyanoacetates, part of a group known as fluorescent molecular rotors, to serve as fluorescent, non-mechanical viscosity sensors. Of particular interest are molecules compatible with aqueous environments. In this study, we present the synthesis and physical characterization of derivatives from 9-(2-carboxy-2-cyanovinyl)-julolidine and related molecules. All compounds show a power-law relationship of fluorescence emission with the viscosity of the solvent, different mixtures of ethylene glycol and glycerol to modulate viscosity. Compounds with high water solubility exhibit the same behavior in aqueous solutions of dextran, where the dextran concentration was varied to modulate viscosity. In addition, some compounds have been found to have low sensitivity towards changes in the pH in the physiological range. The compounds presented show promise to be used in biofluids, such as blood plasma or lymphatic fluid, to rapidly and non-mechanically determine viscosity.
- Haidekker, Mark A.,Brady, Thomas P.,Chalian, Sevag H.,Akers, Walter,Lichlyter, Darcy,Theodorakis, Emmanuel A.
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p. 274 - 289
(2007/10/03)
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- Solvent-free Knoevenagel condensations and Michael additions in the solid state and in the melt with quantitative yield
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Numerous Knoevenagel condensations of solid or liquid aromatic aldehydes are performed with four barbituric acids, Meldrum's acid, dimedone, cyanoacetamide, malodinitrile and methyl cyanoacetate in stoichiometric mixtures of the solids or of stoichiometri
- Kaupp, Gerd,Naimi-Jamal, M. Reza,Schmeyers, Jens
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p. 3753 - 3760
(2007/10/03)
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- Cyanovinylheteroaromatics for Organic Nonlinear Optics
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Effects of various substituents including chromophores on the second harmonic generation (SHG) of cyanovinylheteroaromatics were examined.The molecular polarizability was calculated by the PPP MO method to correlate SHG responsiveness with chemical structures. 3-indole 8b exhibited good SHG efficiency (PE = 25U).The X-ray analysis of 8b showed that the crystals belong to novel and the most favorable P1 space group.
- Matsuoka, M.,Takao, M.,Kitao, T.,Fujiwara, T.,Nakatsu, K.
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- CATALYSIS OF THE KNOEVENAGEL CONDENSATION.
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Xonotlite alone or made more basic by doping of potassium t-butoxide catalyses the title reaction between aromatic aldehydes and malononitrile or alkyl cyanoacetates.At ambient temperatures, this procedure specifically gives high yields of E olefinic Knoe
- Chalais, Stephane,Laszlo, Pierre,Mathy, Arthur
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p. 4453 - 4454
(2007/10/02)
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