- INTEGRIN INHIBITORS
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Disclosed are small molecule inhibitors of αvβ6 integrin, and methods of using them to treat a number of diseases and conditions.
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Paragraph 0119-0120
(2020/03/17)
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- PHEROMONES
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The apple leaf midge and raspberry cane midge pheromones have been found to be acetoxyheptadecenone and acetoxyundecanone, respectively, and uses for the related C9-19 oxoalkyl or oxoalkenyl molecules substituted with a lower alkanoyloxy group are provided, including monitoring population levels of the midge and control of midge populations by disrupting mating patterns.
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Page/Page column 19
(2008/06/13)
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- Tungsten(0) alkylidene complexes stabilized as pyridinium ylides: New aspects of their synthesis and reactivity
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The interaction of dihydropyridines with alkoxycarbene complexes of tungsten has been shown to lead to pyridinium ylid complexes: this transformation has now been applied to the synthesis of a hydroxyl-containing ylid complex by ring-opening of the pentacarbonyl (2-oxacyclopentylidene) tungsten(0) complex and to the synthesis of a series of chiral ylid complexes both from chiral and non-chiral carbene complexes by the use of dihydropyridines and dihydronicotines, respectively. The transfer of the alkylidene moiety of these complexes to nucleophilic olefins will be outlined and discussed. Especially relevant is the interaction of these pyridinium ylid complexes with unsaturated substrates such as dihydropyridines, enamines, and β-alkoxy bis(trimethyl-silyl) ketene acetals. This latter reaction leads to conjugated carboxylic acids, and has been be applied to a new synthesis of a honey bee pheromone, the queen substance.
- Rudler, Henri,Durand-Réville, Thomas
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p. 571 - 587
(2007/10/03)
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- Efficient and Convergent Synthesis of (R)-(-)-10-Methyltridecan-2-one, the Sex Pheromone of the Spotted Cucumber Beetle, by Iron-Mediated Chirality Transfer
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The synthesis of (R)-(-)-10-methyltridecan-2-one, the female sex pheromone of the southern corn root worm (Diabrotica undecimpunctata howardi Barber) in high enantiomeric purity (ee >/= 99percent) and excellent overall yields (75percent, five step
- Enders, Dieter,Jandeleit, Bernd
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p. 1173 - 1176
(2007/10/02)
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- Camphorsulfonamide-Shielded, Asymmetric 1,4-Additions and Enolate Alkylations; Synthesis of a Southern Corn Rootworm Pheromone
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Using readily accessible 10-sulfonamido-isoborneols as regenerable, chiral auxiliaries, highly face-selective C-C-bond formations at Cα and Cβ of carboxylates could be conveniently achieved.Thus, conjugated additions of RCu to enoates (1->2) furnished, after saponification, β-substituted carboxylic acids 3 in 94-98 percent e.e.Similarly, propionates 12 yielded after deprotonation, enolate alkylation, and reductive ester cleveage the (R)-alcohols 15 in 78-98 percent e.e.The acid (+)-3e was converted to the pheromone (-)-11.
- Oppolzer, Wolfgang,Dudfield, Philip,Stevenson, Thomas,Godel, Thierry
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p. 212 - 215
(2007/10/02)
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