A facile synthesis of 4-(trialkylmethyl)anilines by the reaction of 4- (trifluoromethyl)aniline with Grignard reagents
The treatment of 4-(trifluoromethyl)aniline (7) with primary Grignard reagents in ether yields the title products 14 (50-75%). A mechanistic pathway involves a series of fluoride elimination reactions followed by addition of the Grignard reagent to the resultant nonaromatic intermediate after each elimination step.
Lin, Shou-Yuan,Hojjat, Maryam,Strekowski, Lucjan
p. 1975 - 1980
(2007/10/03)
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