- Immobilization of palladium nanoparticles on Metformin-functionalized graphene oxide as a heterogeneous and recyclable nanocatalyst for Suzuki coupling reactions and reduction of 4-nitrophenol
-
In this study, Pd nanoparticles supported on Metformin modified graphene oxide (GO-Met-Pd) is proposed as a green heterogeneous catalyst. The structural properties of the as-synthesized nanocatalyst were determined by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS), wavelength-dispersive X-ray spectroscopy (WDX) and inductively coupled plasma (ICP). Activity of the catalyst was investigated by focusing on the Suzuki-Miyaura coupling reaction and room-temperature reduction of 4-nitrophenol (4-NP), as model reactions. The catalyzed reactions provided high yields of biphenyl compounds through the Suzuki-Miyaura reaction and outlined highly efficient conversion of 4-NP to its reduced form. Moreover, no significant Pd leaching was detected in the reaction solutions and the catalyst could be recovered, at least, 6 times without any considerable loss of its catalytic activity.
- Hemmati, Saba,Mehrazin, Lida,Pirhayati, Mozhgan,Veisi, Hojat
-
-
Read Online
- Pd nanoparticles deposited on Isoniazid grafted multi walled carbon nanotubes: Synthesis, characterization and application for Suzuki reaction in aqueous media
-
In this article a new heterogeneous nanocatalyst based on palladium supported on Isoniazide-functionalized multi-walled carbon nanotubes (MWCNTs) has been introduced. The synthetic process of preparation of the mentioned nanocatalyst (Isoniazide-MWCNTs/Pd
- Hajighorbani, Mahsa,Hekmati, Malak
-
-
Read Online
- Photochemical (Hetero-)Arylation of Aryl Sulfonium Salts
-
The construction of (hetero)biaryls, which are ubiquitous scaffolds among medical substances, functional materials, and agrochemicals, constitutes a key application of cross-coupling methods. However, these usually require multiple synthetic steps. Herein, we report a simple photoinduced and catalyst-free C-H/C-H (hetero)arylation cross-coupling through aryl thianthrenium salts, which are formed site-selectively by direct C-H functionalization. The key to this approach is the UV-light, which can disrupt the C-S bond to form thianthrene radical cations and aryl radicals.
- Zhao, Yue,Yu, Congjun,Liang, Wenjing,Patureau, Frederic W.
-
p. 6232 - 6236
(2021/08/23)
-
- Base-Controlled One-Pot Chemoselective Suzuki-Miyaura Reactions for the Synthesis of Unsymmetrical Terphenyls
-
We report a chemoselective Suzuki-Miyaura reaction protocol of using bromophenyl fluorosulfonate as building block for the preparation of unsymmetrical terphenyls. The chemoselective cross-coupling of bromophenyl fluorosulfonate and arylboronic acids can be achieved by controlling base species without using any ligands. Under this methodology, various of m - and p -unsymmetrical terphenyls were obtained in moderate to good yields.
- Feng, Fangfang,Hu, Qinghong,Li, Xinmin,Ren, Changyue,Teng, Yong,Yuan, Zeli
-
supporting information
p. 2131 - 2135
(2019/11/25)
-
- Furan- and thiophene-2-carbonyl amino acid derivatives activate hypoxia-inducible factor via inhibition of factor inhibiting hypoxia-inducible factor-1
-
Induction of a series of anti-hypoxic proteins protects cells during exposure to hypoxic conditions. Hypoxia-inducible factor-α (HIF-α) is a major transcription factor that orchestrates this protective effect. To activate HIF exogenously, without exposing
- Kawaguchi, Shin-ichi,Gonda, Yuhei,Yamamoto, Takuya,Sato, Yuki,Shinohara, Hiroyuki,Kobiki, Yohsuke,Ichimura, Atsuhiko,Dan, Takashi,Sonoda, Motohiro,Miyata, Toshio,Ogawa, Akiya,Tsujita, Tadayuki
-
-
- N-Doped porous carbon nanotubes: Synthesis and application in catalysis
-
Uniform N-doped carbon nanotubes were obtained for the first time via a morphology-preserving thermal transformation of organic polymer nanotubes without any additional templates. These carbon nanotubes acted as a superior metal-free carbon catalyst for C-H arylation of benzene, reductive hydrogen atom transfer and oxidation reactions.
- Yang, Zhenzhen,Liu, Zhenghui,Zhang, Hongye,Yu, Bo,Zhao, Yanfei,Wang, Huan,Ji, Guipeng,Chen, Yu,Liu, Xinwei,Liu, Zhimin
-
supporting information
p. 929 - 932
(2017/01/17)
-
- Biarylalkyl Carboxylic Acid Derivatives as Novel Antischistosomal Agents
-
Parasitic platyhelminths are responsible for serious infectious diseases, such as schistosomiasis, which affect humans as well as animals across vast regions of the world. The drug arsenal available for the treatment of these diseases is limited; for example, praziquantel is the only drug currently used to treat ≥240 million people each year infected with Schistosoma spp., and there is justified concern about the emergence of drug resistance. In this study, we screened biarylalkyl carboxylic acid derivatives for their antischistosomal activity against S. mansoni. These compounds showed significant influence on egg production, pairing stability, and vitality. Tegumental lesions or gut dilatation was also observed. Substitution of the terminal phenyl residue in the biaryl scaffold with a 3-hydroxy moiety and derivatization of the terminal carboxylic acid scaffold with carboxamides yielded compounds that displayed significant antischistosomal activity at concentrations as low as 10 μm with satisfying cytotoxicity values. The present study provides detailed insight into the structure–activity relationships of biarylalkyl carboxylic acid derivatives and thereby paves the way for a new drug-hit moiety for fighting schistosomiasis.
- M?der, Patrick,Blohm, Ariane S.,Quack, Thomas,Lange-Grünweller, Kerstin,Grünweller, Arnold,Hartmann, Roland K.,Grevelding, Christoph G.,Schlitzer, Martin
-
supporting information
p. 1459 - 1468
(2016/07/16)
-
- Nickel-catalyzed one-pot synthesis of biaryls from phenols and arylboronic acids via C-O activation using TCT reagent
-
In this study, the direct Nickel-catalyzed Suzuki-Miyaura coupling reaction of phenols and arylboronic acids via C-O bond activation using 2,4,6-trichloro-1,3,5-triazine (TCT) is described. Initially, phenols were reacted with TCT to give the corresponding 2,4,6-triaryloxy-1,3,5-triazine (TAT) products. Subsequently, arylboronic acid, base and Ni-catalyst were added to the generated aryl C-O electrophile to obtain the final biaryl product. This study represents a simple and direct method for the synthesis of biaryls from phenolic compounds using sub-stoichiometric amounts of TCT as a cheap and readily available C-O activating reagent.
- Iranpoor, Nasser,Panahi, Farhad,Jamedi, Fereshteh
-
-
- Trisulfur radical anion as the key intermediate for the synthesis of thiophene via the interaction between elemental sulfur and NaO t Bu
-
A facile base-promoted sulfur-centered radical generation mode and a single-step protocol for the synthesis of thiophene derivatives using 1,3-diynes via the interaction between elemental sulfur and NaOtBu has been reported. EPR experiments revealed that the trisulfur radical anion acts as a key intermediate of this process. A plausible mechanism has been proposed.
- Zhang, Guoting,Yi, Hong,Chen, Hong,Bian, Changliang,Liu, Chao,Lei, Aiwen
-
p. 6156 - 6159
(2015/01/16)
-
- One-pot synthesis of functionalized p-terphenyl derivatives
-
A one-pot synthetic route for preparing functionalized p-terphenyl derivatives 1 and 4 is developed. The route is easily carried from the treatment of cinnamyl aldehydes 2 with substituted allylsulfones 3 in good yields via the tandem intermolecular aldol condensation/intramolecular electrocyclization/ oxidative dehydrogenation.
- Chang, Meng-Yang,Chan, Chieh-Kai,Wu, Ming-Hao
-
p. 7916 - 7924
(2013/08/23)
-
- Polymer-supported syntheses of thiophene-containing compounds using a new type of traceless linker
-
A new type of traceless linker is described for use in polymer-supported (PS) syntheses of thiophene-containing compounds. It is based on the cleavage of PS aryl 2-thienyl ketones by a mixture of potassium t-butoxide and water (typical mol ratio 10:3) in an ethereal solvent. Cleavage occurs to give the soluble thiophene-containing product. The method is used to prepare a range of eight thiophene-containing compounds including a terthiophene and a dialkylquaterthiophene. PS unsymmetrical diaryl ketones incorporating, for example, ortho-methoxyphenyl or pyrrole moieties could also serve as traceless linkers.
- Ben-Haida, Abderrazak,Hodge, Philip
-
experimental part
p. 1754 - 1763
(2012/04/23)
-
- Synthesis of thiophene/phenylene co-oligomers. III [1]. Thienyl-capped oligophenylenes
-
The author reports the synthesis of thienyl-capped oligophenylenes via improved synthetic schemes. These schemes are based on either the Grignard or Suzuki coupling reaction and enable the author to obtain the target compounds at appreciably high yields. Regarding several of these compounds, their synthesis and characterization are believed to be reported for the first time. The resulting materials have been fully characterized through the nmr and ir spectroscopy. The ir analysis is particularly useful in characterizing the materials of higher molecular weight, since those materials are difficult to dissolve in organic solvents.
- Hotta
-
p. 923 - 927
(2007/10/03)
-
- Aryl Coupling through Borate Complexes with Ethanolamine.
-
The scope and limitations of aromatic coupling by the action of N-bromsuccinimide on stable diarylethanolamine borate salts are disclosed.The procedure is an excellent, regiospecific procedure for the coupling of furyl and thienyl residues to each other or to aromatic rings in mild conditions and without scrambling.
- Pelter, Andrew,Williamson, Hugh,Davies, Gareth M.
-
p. 453 - 456
(2007/10/02)
-