- PESTICIDAL COMPOSITIONS AND METHODS
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This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules,
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Page/Page column 93
(2020/07/15)
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- Preparation method of benzyl bromide compound
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The invention relates to a method for producing a benzyl bromide compound (I or II). The method has high reaction yield, high product purity, fewer produced three wastes and good environmental compatibility. The method has remarkable economic benefit, social benefit and environmental benefit. The formula is shown in the description.
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Paragraph 0077; 0078
(2019/02/04)
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- COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION
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Disclosed herein are methods for inducing insulin secretion in a glucose-dependent manner and compounds for use in these methods.
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Page/Page column 106; 107
(2018/10/19)
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- A 2 - ( methoxy methyl ) phenyl -1,4-diamine preparation method
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The invention relates to a method for preparing 2-(methoxyl-methyl) phenyl-1,4-diamine. The method comprises the following steps: by taking o-nitrobenzyl alcohol as a raw material, performing methylation and hydrogenation reduction reaction so as to obtai
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Paragraph 0112; 0113
(2016/12/16)
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- Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists
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Optimization starting with our lead compound 1 (IC50 = 4.9 nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward improvement of the bioavailability provided (R)-1-(1-((6-fluoronaphthalen-2-yl)methyl)pyrrolidin-3-yl)-3-(2-(2- hydroxyethoxy)phenyl)urea 32 (IC50 = 1.7 nM), a potent and orally active CCR3 antagonist.
- Nitta, Aiko,Iura, Yosuke,Inoue, Hideki,Imaoka, Takayuki,Takahashi, Toshiya,Sato, Ippei,Morihira, Koichiro,Kubota, Hirokazu,Morokata, Tatsuaki,Takeuchi, Makoto,Ohta, Mitsuaki,Tsukamoto, Shin-Ichi
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p. 6876 - 6881,6
(2020/09/02)
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- Carbamates and crop protection agents containing them
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Carbamates of the formula I STR1 where the substituents have the following meanings: Z is methoxy, NH2, NHCH3, N(CH3)2, CH3, C2 H5, CF3 or CCl3, X and Y are
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- The matrix-isolation IR spectrum of the o-quinonoid intermediate in the photolysis of 2-nitrobenzyl methyl ether
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Photolysis of 2-nitrobenzyl methyl ether in Ar and N2 matrices at 12 K generated an intermediate with λmax at 430 nm, and which was itself photolabile at 430-460 nm. Matrix IR spectra, as well as the UV-visible absorption, were obtai
- Dunkin,Gebicki,Kiszka,Sanin-Leira
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p. 2553 - 2557
(2007/10/03)
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- Ozone-mediated nitration of phenylalkyl ethers, phenylacetic esters, and related compounds with nitrogen dioxide. the highest ortho substitution observed in the electrophilic nitration of arenes
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By the combined action of ozonized oxygen and nitrogen dioxide (the kyodai-nitration), the title compounds were smoothly nitrated in dichloromethane at subzero degrees with hiigh ortho positional selectivity. Although the conventional nitration of phenylacetic acid and esters mainly produces m- and p-nitro derivatives, the present nitration offers a simple high-yield synthesis of o-nitro derivatives which are important as precursor in organic synthesis. The proportions of the ortho isomer in the nitration products from methyl 2-phenylethyl ether and methyl phenylacetate were 71 and 88%, respectively, the latter value being the highest ortho isomer proportion so far observed in the electrophilic aromatic nitration. The observed high ortho selectivity has been rationalized in terms of radical cation intermediate and six-membered cyclic transition state.
- Suzuki, Hitomi,Takeuchi, Toyomi,Mori, Tadashi
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p. 5944 - 5947
(2007/10/03)
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- REACTIVITY OF THE ACIDS OF TRIVALENT PHOSPHORUS AND THEIR DERIVATIVES. PART IV. THE REACTION OF DIALKYLPHOSPHITE ANIONS WITH NITROBENZYL BROMIDES
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The reaction of o-, m- and p-nitrobenzyl bromide with sodium dimethylphosphite as well as sodium diisopropylphosphite in THF and alcohols as the solvent is described.According to the constitution of the starting materials and the solvents used, the formation of the P-C bond, debromination or dimerization occurs.The principal process in o- and p-nitrobenzyl bromide and >P-O- anion systems is believed to be X-philic substitution, the dimer is formed through a secondary process via SET from the nitrobenzyl anion to nitrobenzyl bromide.Electron-transfer and proton-transfer processes in the nitrobenzyl bromide->P-O- systems are also discussed.Key words: o-, m- and p-nitrobenzyl bromides, dialkyl phosphites, Michaelis-Becker reaction, X-philic substitution, SET.
- Witt, Dariusz,Rachon, Janusz
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- α-AMINO CARBANIONS. A SECOND GENERATION FORMAMIDINE FOR FACILE DEPROTONATION LEADING TO α-QUATERNARY SUBSTITUTION
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Formamidines derived from o-methoxymethylaniline (MMA) allow proton removal of tertiary protons in 1-substituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines.
- Gonzales, Michael A.,Meyers, A. I.
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- Synthesis and Dediazoniation of 2-Butyl- and 2,5-Dibutylbenzenediazonium Ions
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2-Butylbenzenediazonium ion (1a) and 2,5-dibutylbenzenediazonium ion (1b) have been thermally decomposed in aqueous acid solution.In addition to the major product, the corresponding phenol, 5- and 6-membered ring products are formed (in a ratio of ca. 7:1) as well as products of elimination and substitution in the o-butyl group.The formation of the non-phenolic products is explained in terms of competing reactions of the initially formed aryl cations: cyclization by electrophilic atttack on the o-butyl group and 1,5-hydride ion transfer from the o-butyl group with concomitant elimination or reaction with the medium.Decompositions of 1a in the presence of copper(I) oxide, believed to generate aryl radicals, does not yield any measurable quantities of cyclized products, however.
- Sikkar, Rein,Martinson, Per
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p. 551 - 558
(2007/10/02)
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