- FLUORINATED ALLENES: THE SYNTHESES OF 1-FLUOROPROPADIENE, 1,1-DIFLUOROPROPADIENE AND 1,1-DIFLUORO-3-METHYL-1,2-BUTADIENE
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Improved syntheses of 1-fluoropropadiene and 1,1-difluoropropadiene are presented as is the synthesis of a third reactive allene, 1,1-difluoro-3-methyl-1,2-butadiene.Gram quantities of these highly reactive fluorinated allenes may be prepared conveniently in high yield and purity.All three are reactive dienophiles and cycloadd regiospecifically using their non-fluorine-substituted double bonds.
- Dolbier, William R.,Burkholder, Conrad R.,Piedrahita, Carlos A.
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- ION CHANNEL MODULATORS
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The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.
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Page/Page column 48
(2021/06/04)
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- Nucleophilic trifluoromethylation using trifluoromethyl iodide. A new and simple alternative for the trifluoromethylation of aldehydes and ketones
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(Matrix Presented) A novel method for nucleophilic trifluoromethylation of aldehydes and ketones, based on photoinduced reduction of trifluoromethyl iodide by tetrakis(dimethylamino)ethylene (TDAE), is presented.
- Ait-Mohand, Samia,Takechi, Naoto,Medebielle, Maurice,Dolbier Jr., William R.
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p. 4271 - 4273
(2007/10/03)
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