- Catalyst-Free Hydrodefluorination of Perfluoroarenes with NaBH4
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Presented is an economical means of removing fluorine from various highly fluorinated arenes using NaBH4. The procedure was adapted for different classes of perfluoroarenes. A novel isomer of an emerging class of organic dyes based on the carbazole phthalonitrile motif was succinctly synthesized in two steps from tetrafluorophthalonitrile, demonstrating the utility of the hydrodefluorination procedure. Initial exploration of the dye shows it to be photoactive and capable of facilitating contrathermodynamic styrenoid E/Z isomerization.
- Schoch, Timothy D.,Mondal, Mukulesh,Weaver, Jimmie D.
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p. 1588 - 1593
(2021/03/03)
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- Method for preparing 3, 5-difluoro-4-chloro-nitrobenzene through diazotization
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The invention belongs to the technical field of organic chemical industry and relates to a method for synthesizing a 3, 5-difluoro-4-chloro-nitrobenzene chemical intermediate, in particular to a method for synthesizing 3, 5-difluoro-4-chloro-nitrobenzene by using 2, 4-difluoro-3-chloro-6-nitrobenzene as a raw material and adopting a diazotization deamination one-pot process, wherein reaction yield reaches 90%. The method has the advantages of high product selectivity, simple and controllable process, low production cost and low three-waste yield.
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Paragraph 0019; 0020; 0021; 0022; 0023; 0024; 0025-0032
(2017/04/26)
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- Charge control in the S(N)Ar reaction. Meta substitution with respect to the activating nitro group in 3,4-dihalogenonitrobenzenes
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The reactions of 3-fluoro-4-chloronitrobenzene and of 3,5-difluoro-4-chloronitrobenzene with thiophenoxide anion lead to predominant substitution of the chlorine atom through S(N)Ar orbital-controlled processes. However, when harder nucleophiles (methoxide anion) are used, the substitution of a fluorine atom meta with respect to the activating nitro group becomes apparent in the reaction of 3-fluoro-4-chloronitrobenzene, predominant in the reaction of 5-fluoro-4-chloro-3-methyoxynitrobenzene, and almost exclusive in the reaction of 3,5-difluoro-4-chloronitrobenzene. Kinetic measurements and theoretical calculations indicate that the observed meta substitution of a fluorine atom is a S(N)Ar charge-controlled reaction with a loosely bonded transition state.
- Cervera,Marquet,Martin
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p. 2557 - 2564
(2007/10/03)
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